Knowledge for Use in Practice

Knowledge for Use in Practice delves deep into medical research, providing practical solutions for pressing health concerns that impact all of society. This conference showcases cutting-edge developments in healthcare, ensuring that scientific breakthroughs are not just theoretical, but applied to create real-world health solutions.

The main sections of Knowledge for Use in Practice conference are listed below.

The Role of Dysregulated Immune Responses and Infection in Disease Pathology

26–28 March, Hippocrates Lecture Hall, RSU, 16 Dzirciema iela

26 March. Perspective Strategies to Overcome Antibacterial Resistance and Tackle Hard-to-Treat Infections. Agenda

As the threat posed by multidrug-resistant pathogens intensifies, we find ourselves at a critical juncture where antibiotic treatment is increasingly ineffective. Phage therapy has emerged as a promising alternative and, in some instances, the only viable option for the patient. Unlike broad-spectrum antibiotics, phages target only specific bacteria, thus not disturbing the microbiota.

The abundance of phages and their interaction with bacteria have shown that phages could complement or even replace antibiotics in the fight against infections. The research in phage application in medicine and other spheres is flourishing and has demonstrated immense potential for the future treatment of difficult-to-treat infections.

Agenda

Session I: Current Landscape of Antibacterial Resistance in Latvia Chair: Asst. Prof. Kārlis Rācenis (Latvia), Prof. Ludmila Vīksna (Latvia)
9:00–9:20	Practical Implications of AMR Research in Latvia Uga Dumpis, Latvia
9:20–9:34	Antimicrobial Resistance Related Mortality in the Clinical University Hospital of Latvia Ieva Voita, Latvia
9:34–9:48	Healthcare-Associated Infections and Antimicrobial Resistance: A Point Prevalence  Study in a Tertiary Care Hospital Anna Žilde, Latvia
9:48–10:02	Bacteremia Surveillance as an Antimicrobial Resistance Limiting Tool Liāna Linda Skrauča, Latvia
10:02–10:16	Antimicrobial Resistance Profile of Pseudomonas aeruginosa in a Level IV Healthcare Institution in Latvia from 2011 to 2024 Evija Skrode, Latvia
10:16–10:30	Mycoplasma Pneumoniae Detection and Characterisation, 2023–2024 Diāna Dušacka, Latvia
10:30–11:00	Break
Session II: Phage Therapy: A Forgotten Cure Rediscovered? Chair: Prof. Uga Dumpis (Latvia), Asst. Prof. Saija Kiljunen (Finland)
11:00–11:15	Phage Therapy in Human Medicine Kārlis Rācenis, Latvia
11:15–11:30	History of Phage Therapy Juta Kroiča, Latvia
11:30–12:00	Phage Therapy in Belgium Jean-Paul Pirnay, Belgium
12:00–12:30	Transfer of Intestinal Phageome to the Blood and Its Regulation by the Immune System Krystyna Dąbrowska, Poland
12:30–13:30	Break
Session III: Phage Isolation and Characterization – Establishing Effective Phage Bank Chair: Prof. Juta Kroiča (Latvia), Dr. Jean-Paul Pirnay (Belgium)
13:30–14:00	S. aureus RM-Systems and the Selection of Phage Production Host Saija Kiljunen, Finland
14:00–14:15	Isolation and Characterization of Bacteriophages Targeting Fish-Pathogenic Aeromonas spp. Karīna Švānberga, Latvia
14:15–14:30	From Superbugs to Super Solutions: Testing Susceptibility of E.coli Against Bacteriophage Cocktails – Preliminary Results Lise Berentsen, Latvia
14:30–14:45	Propagation of the Acquired Virulence Traits by the Multi-Drug Resistant Carbapenemase-Producing Klebsiella pneumoniae in the Hospital Network in Latvia Baiba Niedre-Otomere, Latvia
14:45–15:00	First Steps Towards the Latvian Klebsiella spp. Bacteriophage Biobank Ņikita Zrelovs, Latvia
15:00–15:30	Break
Session IV: Material Sciences and Phages Chair: Prof. Krystyna Dąbrowska (Poland), Assoc. Prof. Ingus Skadiņš (Latvia)
15:30–16:00	Hydroxyapatite Modification with Zinc and Bacteriophages for the Development of Novel Antibacterial Biomaterials Līga Stīpniece, Latvia
16:00–16:15	Titanium Plate Modifications and Biopolymer Matrices: Innovative Strategies Towards Preservation of Bacteriophage Stability and Release Profile Dace Rezevska, Latvia
16:15–16:30	Bacteriophages as a Model for Antiviral Susceptibility Detection on Metal Surfaces Renārs Broks, Latvia
16:30–16:45	Advanced Hydrogel Platforms: Cross-Linked Polypeptide for Non-Antibiotic Antibacterial Applications Artemijs Ščeglovs, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #5 Committee: Asst. Prof. Aigars Reinis (Latvia), Dace Rudzīte (Latvia)
10:30–11:00	Investigating the Incidence of ESKAPE Organism-Associated Bloodstream Infections Across Multiple Departments at Pauls Stradiņš Clinical University Hospital During 2021–2023 Vinay Mulukutla, Latvia
10:30–11:00	Prevalence and Tetracycline Resistance of Ureaplasma Species and Mycoplasma hominis in Latvia from 2014 to 2024 Linda Maule, Latvia
10:30–11:00	The Results of Wastewater Surveillance for Non-Polio Enteroviruses in Latvia 2024 Gatis Pakarna, Latvia
Committee: Assoc. Prof. Ingus Skadiņš (Latvia), Asst. Prof. Monta Madelāne (Latvia)
12:30–13:30	Phenotypic Characterization of Different Salmonella enterica Serotypes in Latvia 2022–2023 Anastasija Kozira, Latvia
12:30–13:30	Trends in Pneumocystis jirovecii Infections: A 5-Year PCR-Based Study in National Microbiology Reference Laboratory of Latvia Lāsma Eglīte, Latvia
Committee: Asst. Prof. Aigars Reinis (Latvia), Dace Rudzīte (Latvia)
12:30–13:30	Detection, Isolation and Whole Genome Sequencing of Campylobacter ureolyticus Isolate from Non-Diarrheal Sample in National Microbiology Reference Laboratory of Latvia Ināra Kampenusa, Latvia
12:30–13:30	The Diversity and AMR Gene Profiles of the Campylobacter jejuni and Campylobacter coli Clinical Isolates, Genotyped in National Microbiology Reference Laboratory During September 2022 – October 2024 Ināra Kampenusa, Latvia
Committee: Asst. Prof. Aigars Reinis (Latvia), Assoc. Prof. Rudīte Koka (Latvia)
15:00–15:30	Analysis of Potential Fungal Infection Causative Agents Isolated from Skin and Its Derivates in CL 2022–2023 Ivo Siņicins, Latvia
15:00–15:30	In Vitro Antibacterial Effect of Five Essential Oils Against Human Pathogens Nils Vamža, Latvia

27 March. Immunology and Neuroimmunology in Research and Clinical Practice. Agenda

This section focuses on the comprehensive study of primary immunodeficiencies and autoimmune diseases, with a particular emphasis on neurological autoimmune disorders and their complex underlying pathogenesis. It also delves into the investigation of hereditary angioedema and chronic spontaneous urticaria, two key areas in the study of immunological disorders. Additionally, the section explores various forms of allergies and secondary immunodeficiencies, examining their triggers, mechanisms, and impacts on the immune system. Through a multidisciplinary approach, this research seeks to advance the understanding of these conditions and contribute to the development of innovative diagnostic and therapeutic strategies.

Agenda

Session I: Inborn Errors of Immunity Chair: Prof. Nataļja Kurjāne (Latvia), Prof. Kai Kisand (Estonia)
9:00–9:20	Autoantibodies to Cytokines: Friends or Foes? Kai Kisand, Estonia
9:20–9:40	Inflammatory Profile of Macrophages Activated by Viral Oligomeric Proteins Aurelija Žvirblienė, Lithuania
9:40–10:00	Treatment Compliance in Patients with Inborn Errors of Immunity Anastasia Bondarenko, Ukraine
10:00–10:20	Early Identification of Immunodeficiencies: Results from the First Year of SCID Screening in Latvia Marija Rozevska, Latvia
10:20–10:30	Discussion Nataļja Kurjāne, Latvia
10:30–11:00	Break
Session II: Neuroimmunology Chair: Assoc. Prof. Viktorija Ķēniņa (Latvia), Jakob Theorell (Sweden)
11:00–11:30	Autoantigen-Specific T-Cell Responses in Neurological Autoimmune Diseases Carina Saggau, Germany
11:30–12:00	A Digital Framework for Cell-Cased Assay Interpretation for Autoimmune Encephalitis Jakob Theorell, Sweden
12:00–12:30	Exploring the Diagnostic Potentials of miRNA in Autoimmune Neuropathies Edita Kuncevičienė, Lithuania
12:30–13:30	Break
Session III: Allergy Chair: Prof. Nataļja Kurjāne (Latvia), Prof. Anastasia Bondarenko (Ukraine)
13:30–14:00	The Prevalence of Extrinsic Endotype of Atopic Dermatitis in Children on BLW Olena Sharikadze, Ukraine
14:00–14:20	Unraveling the Mystery of Beta-Lactam Hypersensitivity: Insights from Vilnius University Hospital Santaros Klinikos Kotryna Linauskienė, Lithuania
14:20–14:40	Diagnosing Contact Allergy: From Rare Sensitizers to Occupational Outbreaks – Lessons from Tribenoside, Bakuchiol, and Dicyclohexylcarbodiimide Laura Malinauskienė, Lithuania
14:40–15:00	Heat Shock Proteins in Hives: Investigating HSP70 and Anti-HSP70 in Chronic Spontaneous Urticaria Lāsma Lapiņa, Latvia
15:00–15:30	Break
Session IV: Neuroimmunology Chair: Assoc. Prof. Viktorija Ķēniņa (Latvia), Prof. Anna Rostedt Punga (Sweden)
15:30–16:00	Serum Protein Biomarker Profile Distinguishes Acetylcholine Receptor Antibody Seropositive Myasthenia Gravis Patients from Healthy Controls Anna Rostedt Punga, Sweden
16:00–16:30	Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis Liis Väli, Estonia
16:30–16:50	Two-Year Follow-Up Study of Myasthenia Gravis Patients: A Single Centre Experience Arta Grosmane, Latvia
16:50–17:00	Discussion and closing remarks Viktorija Ķēniņa, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #5
10:30–11:00	Serum B-Cell Activating Factor (BAFF) Levels Are Unrelated to SARS-CoV-2-Specific T-Cell and Spike-Specific Antibody Responses Zane Lucāne, Latvia
10:30–11:00	Longitudinal Study of Antibody Dynamics in Healthcare Workers During Successive Periods of SARS-CoV-2 Variant Dominance Tadas Alčauskas, Lithuania
12:30–13:30	Component Resolved Diagnostic vs. Skin Prick Test: Diagnostic Test Comparison Marc Meyer, Latvia
12:30–13:30	Antibody Specific Index (AI) in Inflammations of the Facial and Vestibulocochlear Nerve Holger Schmidt, Latvia
12:30–13:30	Immunological Profile in Patients with Chronic Autoimmune Neuropathies Nataļja Kurjāne, Latvia
12:30–13:30	Comorbidities in Hereditary Angioedema (HAE) Patients in Latvia: A Clinical and Epidemiological Assessment Adīne Kaņepa, Latvia

28 March. Infection-Associated Non-Communicable Diseases. Agenda

"Infection associated non-communicable diseases" delves into the critical role of infections in the onset and progression of non-communicable diseases, emphasizing how host-pathogen interactions contribute to autoimmune conditions. Topics will include the latest research on infections as triggers for chronic diseases, the discovery of novel biomarkers, and cutting-edge detection methods. Through these discussions, the section aims to illuminate the connections between infectious processes and long-term health outcomes, driving forward both research and clinical strategies.

Agenda

Session I: Metabolic and Immune Dysregulation in ME/CFS and Related Disorders: From Pathophysiology to Therapeutic Strategies Chair: Assoc. Prof. Modra Murovska (Latvia), Prof. François Jérôme Authier (France)
9:00–9:45	Metabolic Adaptation and Fragility in Healthy 3-D in vitro Skeletal Muscle Tissues Exposed to Chronic Fatigue Syndrome and Long COVID-19 Sera Javier Ramón Azcón, Spain
9:45–10:00	Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Long COVID: Shared Challenges and Opportunities in Chronic Disease Management Diāna Arāja, Latvia
10:00–10:15	Disease-Targeted Physical Activity Program as a Therapeutic Strategy for Fibromyalgia: A Pilot Study Yuri Ostrinski, Latvia
10:15–10:30	Association of Baseline Lipopolysaccharide Binding Protein with EDSS Dynamics in Patients with Relapsing-Remitting Multiple Sclerosis Anda Vilmane, Latvia
10:30–11:00	Break
Session II: Post-COVID Syndrome: Neuromuscular, Hepatic, and Immunological Perspectives on Long-Term Health Impacts Chair: Zaiga Nore-Krūkle (Latvia), Prof. Javier Ramón Azcón (Spain)
11:00–11:45	Neurocognitive and Myological Features in Post-Acute COVID Syndrome François Jérôme Authier, France
11:45–12:00	Dynamics of Liver Injury in the Post-COVID Period Ieva Vanaga, Latvia
12:00–12:15	Hepatobiliary Inflammation in Patients Having History of Covid-19 Romans Uļjanovs, Latvia
12:15–12:30	The Connection Between Autoimmune Hepatitis and the Microbiome Anna Marija Prince, Latvia
12:30–13:30	Break
Session III: Enhancing Precision in Hematologic Research: Epstein-Barr Virus, Immune Cell Dynamics, and Advances in Single-Cell Proteomics Chair: Šimons Svirskis (Latvia), Irina Holodņuka (Latvia)
13:30–13:45	EBV Infection Affects Immune Cell Mobility in Treatment-Naïve Patients with Chronic Lymphocytic Leukemia Irina Holodņuka, Latvia
13:45–14:15	Advancing Single-Cell Proteomics: Novel Image Processing Tools for High-Resolution Analysis Mohammadreza Azimi, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #5 Commitee: Šimons Svirskis (Latvia), Irina Holodņuka (Latvia)
10:30–10:40	Analysis of Bile Samples in the Context of COVID-19 Consequences Oksana Koļesova, Latvia
10:40–10:50	Evaluation of Hepatobiliary Microcirculation and Fibrosis in Patients Having History of COVID-19 Ilze Štrumfa, Latvia
10:50–11:00	Health Status After the COVID-19: A Two-Year Longitudinal Study Ieva Vanaga, Latvia

Keynote Speakers

Perspective Strategies to Overcome Antibacterial Resistance and Tackle Hard-to-Treat Infections

Prof. Jean-Paul Pirnay

Queen Astrid Military Hospital, Belgium

Assist. Prof. Saija Kiljunen

University of Helsinki, Finland

Prof. Krystyna Dąbrowska

Wroclaw University of Science and Technology, Poland

Immunology and Neuroimmunology in Research and Clinical Practice

Prof. Liis Väli

Clinic of Neurology, University of Tartu, Estonia

MD, PhD Kai Kisand

Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia

Prof. Olena Sharikadze

Institute of Postgraduate Education, Shupyk National Healthcare University of Ukraine

Jakob Theorell

The Karolinska Institute, Sweden

Carina Saggau

University Medical Center Schleswig-Holstein, Germany

MD, PhD Anna Rostedt Punga

Uppsala University, Sweden

Kotryna Linauskienė

Vilnius University Hospital Santaros Klinikos, Lithuania

Prof. Anastasiia Bondarenko

European Medical School, International European University, Kyiv, Ukraine

Edita Kuncevičienė

Lithuanian University of Health Sciences, Lithuania

Laura Malinauskienė

Vilnius University Faculty of Medicine, Lithuania

Prof. Aurelija Žvirblienė

Vilnius University, Lithuania

Infection Associated Non-Communicable Diseases

Prof. Javier Ramón Azcón

Institute for Bioengineering of Catalonia, Spain

MD, PhD François Jérôme Authier

Paris-East Créteil University, France

Scientific Committee

Perspective Strategies to Overcome Antibacterial Resistance and Tackle Hard-to-Treat Infections

• Jean-Paul Pirnay, PhD, Queen Astrid Military Hospital, Head of the Laboratory for Molecular and Cellular Technology, Belgium
• Asst. prof. Saija Kiljunen, PhD, Human Microbiome Research Program, Faculty of Medicine, University of Helsinki PrecisionPhage Ltd, Jyväskylä, Finland
• Prof. Krystyna Dabrowska, PhD, Laboratory of Phage Molecular Biology, Institute of Immunology and Experimental Therapy, Wrocław, Wrocław University of Science and Technology, Faculty of Medicine, Wrocław, Research and Development Center, Regional Specialist Hospital, Wrocław, Poland
• Prof. Juta Kroiča, MD, PhD, Department of Biology and Microbiology, Rīga Stradiņš University
• Prof. Ludmila Vīksna, Md, PhD, Department of Infectology, Rīga Stradiņš University; Riga East University Clinical Hospital
• Asst. Prof. Kārlis Rācenis, MD, PhD, Department of Biology and Microbiology, Department of Internal Diseases, Rīga Stradiņš University; Nephrology Centre, Pauls Stradins Clinical University Hospital
• Researcher Ņikita Zrelovs, PhD, Department of Biology and Microbiology, Rīga Stradiņš University, Latvian Biomedical Research and Study Centre
• Asst. prof. Monta Madelāne, MD, PhD, Department of Infectology, Rīga Stradiņš University; Department of Infection Control, Riga East University Clinical Hospital

Immunology and neuroimmunology in Research and clinical practice

• Prof. Kai Kisand, Cellular Immunology at the Institute of Biomedicine and Translational Medicine, the University of Tartu, Estonia 
• Prof. Aurelija Žvirbliene, Head of the Department of Immunology and Cell Biology, Institute of Biotechnology of Vilnius University
• Shahar Shelly, MD, PhD, Director of Neuromuscular centre, Institute of Pathology, Rambam Medical Center, Haifa, Israel
• Prof. Nataļja Kurjāne, Department of Biology and Microbiology, Rīga Stradiņš University; lead researcher at the Scientific Laboratory of Molecular Genetics, RSU; Head of the Centre of Clinical Immunology and Allergology, Pauls Stradins Clinical University Hospital
• Assoc. Prof. Viktorija Ķēniņa, Department of Biology and Microbiology, Rīga Stradiņš University; lead researcher at the Scientific Laboratory of Molecular Genetics; Head of the Centre of Rare Neurological diseases,  Pauls Stradins Clinical University Hospital
• Dr. med. Zaiga Nora-Krūkle, Director, Institute of Microbiology and Virology, Rīga Stradiņš University

Infection Associated Non-Communicable Diseases

• Dr. med. Zaiga Nora-Krūkle, Director, Institute of Microbiology and Virology, Rīga Stradiņš University
• Dr. med. Modra Murovska, Lead Researcher, Institute of Microbiology and Virology, Rīga Stradiņš University
• Dr. med. Šimons Svirskis, Lead Researcher, Institute of Microbiology and Virology, Rīga Stradiņš University
• Dr. med. Alīna Sultanova, Lead Researcher, Institute of Microbiology and Virology, Rīga Stradiņš University
• Asst. Prof. Dr. med. Anda Kadiša, Lead Researcher, Institute of Microbiology and Virology, Rīga Stradiņš University
• Dr. biol. Irina Holodņuka, Lead Researcher, Institute of Microbiology and Virology, Rīga Stradiņš University
• Dr. med. Bhupesh Kumar Prusty, Tenured Professor, Institute of Microbiology and Virology, Rīga Stradiņš University
• Gilad Halpert, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel
• Prof. Dario Di Luca, Dept. Medical Sciences, University of Ferrara, Italy
• Daria Bortolotti, Department of Chemical, Pharmaceutical and Agricultural Science, University of Ferrara, Italy
• Prof. Marion Schneider, Clinic for Anaesthesiology and Intensive Care Medicine, Ulm University Hospital, Germany

Main Topics

• Clinical microbiology
• Vaccination
• Antimicrobial resistance
• Nosocomial infections
• Treatment methods for hard-to-treat infections
• Phage therapy
• Immunology
• Neuroimmunology
• Host-pathogen interaction
• Infections in the development of non-communicable diseases
• Autoimmunity

Treatment and Quality Improvement in Healthcare

26–28 March, Auditorium #3, RSU, 16 Dzirciema iela

26 March. Oncology and Hematology – Biomarker-Driven Precision Medicine. Agenda

In the session distinguished international faculty and local cancer experts/researchers will present the results of their latest studies. Mirjam Blattner-Johnson will give an update in the advances in pediatric brain tumor research. Prof. Jacek Gronwald and Prof. Arcangela De Nicolo will uncover cutting edge studies on BRCA1/2 carriers – both clinical and molecular aspects in prevention and management of cancer. The topics in personalized cancer medicine and biomarkers research will include genetic population screening of hereditary breast and ovarian cancer, epidemiology and phenotype/genotype correlations of breast and ovarian cancer predisposition genes, as well as microbiome studies during the cancer treatment.

Agenda

Session I: Advances in Hereditary Breast and Ovarian Cancer Precision Medicine Chair: Prof. Jānis Gardovskis (Latvia), Prof. Edvīns Miklaševičs (Latvia)
9:00–9:30	Detection of a New Breast Cancer Gene – Example of the ATRIP Gene Jacek Gronwald, Poland
9:30–10:00	Genetic Testing for Breast Cancer Susceptibility: The BRCA Genes as a Model for Variant Interpretation, Classification, and Reporting Arcangela De Nicolo, Latvia
10:00–10:15	BRCA1/2 Genetic Population Screening: Are We Ready? Zanda Daneberga, Latvia
10:15–10:30	Genotype / Phenotype Correlation in BRCA1 Founder Variants Pēteris Loža, Latvia
10:30–11:00	Break
Session II: From Diagnosis to Treatment – Various Cancers Chair: Prof. Zanda Daneberga (Latvia), Assoc. Prof. Arvīds Irmejs (Latvia)
11:00–11:15	The Role of Breast MRI in Early Cancer Detection Among BRCA1/2 Mutation Carriers: A Retrospective Cohort Analysis Elīna Auziņa, Latvia
11:15–11:30	Epidemiology of Hereditary Ovarian Cancer Nora Kriķe, Latvia
11:30–11:45	Novel Nipple Reinnervation Technique Using n.suralis Jānis Lapiņš, Latvia
11:45–12:00	Gut Microbiome Analysis in Breast Cancer Patients with Neo-Adjuvant Therapy Elza Elizabete Liepiņa, Latvia
12:00–12:15	Statins as Adjuvant Therapy for Colorectal Cancer Francisco Alejandro Lagunas Rangel, Latvia
12:15–12:30	Clinical Characteristics and Treatment of Gallbladder Cancer: A 5-year Retrospective Analysis from Tertiary Referral Hospital Ms. Anna Sviksa, Latvia
12:30–13:30	Break
Session III: Paediatric Oncology Chair: Dr. Mirjam Blattner-Johnson (Germany)
13:30–14:00	TP53 Alterations Across Subtypes of Paediatric High-Grade Gliomas. Is a Loss of Function a Real Loss of Function? Mirjam Blattner-Johnson, Germany
14:00–14:15	Precision Medicine in Laboratory – Opportunities and Challenges Dace Enkure, Latvia
14:15–14:30	Practical Application of Molecular Genetic Testing in Paediatric Oncology Anna Valaine, Latvia
14:30–14:45	An Extraordinary Paediatric Case with Multiple Paragangliomas with Possible Hydatidiform Mole Origin Rasa Insberga, Latvia
14:45–15:00	Comprehensive Genomic Profiling and the Molecular Landscape of Paediatric ALL in Latvia Egija Berga-Švītiņa, Latvia
15:00–15:30	Break
Session IV: From Diagnosis to Treatment – Various Cancers Chair: Dr. Inese Čakstiņa-Dzērve (Latvia)
15:30–15:45	Antigen-Specific B Cell Responses in Treatment Naïve and Chemotherapy-Receiving Chronic Lymphocytic Leukaemia Patients Roberts Kārkliņš, Latvia
15:45–16:00	Contemporary Insights into Molecular-Genetic Spectrum of Chronic Myeloid Leukaemia Vasile Musteata, Moldova
16:00–16:15	Can We Make “Smarter” Chemotherapy Drug Combinations? Inese Čakstiņa-Dzērve, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #1

Committee: Prof. Zanda Daneberga (Latvia), Asst. Prof. Inese Čakstiņa-Dzērve (Latvia)
10:30–11:00	Prognostic Value of TGF-β in Breast Cancer Patients Oleksandr Mushii, Ukraine
10:30–11:00	The Effect of Lectin on the Proliferative Activity of Breast Cancer Cells in the in vitro System Oleksandr Mushii, Ukraine
12:30–13:30	A Bioinformatic Analysis and the Literature Review on Transcription of Epstein-Barr Virus Encoded Latent Genes in Chronic Leukocytic Leukemia B-Cells Larysa Kovalevska, Ukraine

Screen #4

Committee: Asst. Prof. Jeļena Maksimenko (Latvia), Linda Gailīte (Latvia)
10:30–11:00	Interactions Between BRAF V600 and NRAS Mutations, Tissue Characteristics and Survival in Cutaneous Melanoma Madara Kreišmane, Latvia
10:30–11:00	TNBC in vitro: The Role of Physiologically Relevant Conditions Olesja Rogoza, Latvia
12:30–13:30	The MicroRNA Profile of Rectal Cancer Linda Kokaine, Latvia
12:30–13:30	Different Trends of Expression Pattern of MRPS18-2 and KLF-4, -6 in Medulloblastoma Samples Elena Kashuba, Latvia
12:30–13:30	The Impact of Waiting Time Until Surgery on Tumor Pathomorphosis in Rectal Cancer Following Neoadjuvant Chemoradiation Therapy Linda Kokaine, Latvia
12:30–13:30	The Characteristics of Aggressive Extranodal Non-Hodgkin Lymphomas in Young Adults Dumitrita Urescu, Moldova
Committee: Prof. Zanda Daneberga (Latvia), Asst. Prof. Inese Čakstiņa-Dzērve (Latvia)
15:00–15:30	COL1A1 and COL3A1 Genes Expression as Markers for Bone Metastasis Development in Prostate Cancer Patients Taras Zadvornyi, Ukraine
15:00–15:30	The Relationship Between Collagen Matrix Remodeling Proteins and the Clinical Status of Breast Cancer Patients Oleksandr Mushii, Ukraine

27 March. Transforming Care: Treatment Quality Improvement in Kidney Disease and Beyond. Agenda

This session will explore the comprehensive utility of kidney disease registries in understanding disease progression, optimizing treatment responses, and assessing cost-effectiveness in chronic kidney disease (CKD) management. Discussions will delve into cutting-edge research on IgA nephropathy (IgAN) pathogenesis, highlighting the pivotal roles of B cells and other biomarkers.

The use of renal biopsy registries for detailed analysis of IgAN progression will be examined, alongside strategies for effective disease surveillance and quality control in chronic conditions. Attendees will gain a comprehensive understanding of how registry data can drive advancements in both scientific research and clinical practice.

Agenda

Session I: Advancing Kidney Disease Management Through Data and Demographics Chair: Asst. Prof. Kārlis Rācenis (Latvia), Assoc. Prof. Ieva Ziediņa (Latvia)
9:00–9:30	Kidney Disease in Aging Societies Kitty J. Jager, Netherlands
9:30–10:00	Registries and the Cause of Kidney Failure Alberto Ortiz Arduan, Spain
10:00–10:30	How Do International Renal Registry Comparisons Move the Renal Community Forward? Vianda S. Stel, Netherlands
10:30–11:00	Break
Session II: Enhancing Kidney Care in Latvia: Data-Driven Insights and Future Directions Chair: Prof. Kitty J. Jager (Netherlands), Prof. Aivars Pētersons (Latvia)
11:00–11:15	Kidney Registry in Latvia – Current Status and Future Perspectives Viktorija Kuzema, Latvia
11:15–11:30	Kidney Replacement Therapy in Latvia: Five-Year Analysis of Demographics, Trends, and Regional Disparities Anna Proskurina, Latvia
11:30–11:45	Peritoneal Dialysis Trends in Latvia Ilze Puide, Latvia
11:45–12:00	Improving the Effectiveness of Chronic Kidney Replacement Therapy in Latvia: A Quality and Cost Framework Based on the Latvian Kidney Disease Registry Kārlis Rācenis, Latvia
12:00–12:20	Harnessing Data Standardisation for Success in Value-Based Programmes Daiga Behmane, Latvia
12:30–13:30	Break
Session III: Trends and Innovations in Renal Disease Management Chair: Assoc. Prof. Vianda S. Stel (Netherlands), Assoc. Prof. Viktorija Kuzema (Latvia)
13:30–13:50	Renal Replacement Therapy Changes During 10-Year Period in Lithuania Edita Žiginskienė, Lithuania
13:50–14:10	Results of Epidemiological Studies on Acute and Chronic Kidney Disease in Estonia Mai Rosenberg, Estonia
14:10–14:40	From Codes to Computation: The Norwegian Renal Registry, Structured Reporting, and the Potential of Digital Pathology in Kidney Biopsies Sabine Leh, Norway
14:40–15:00	IgA Nephropathy and Beyond: Biopsy-Driven Insights into Glomerulopathies at Vilnius University Hospital Aistė Račaitė, Lithuania
15:00–15:30	Break
Session IV: IgA Nephropathy Unveiled: Disease Mechanisms and Perspectives Chair: Assoc. Prof. Viktorija Kuzema (Latvia), Asst. Ilze Puide (Latvia)
15:30–15:45	Trends of Biopsy Data and Prevalence of Kidney Diseases at Pauls Stradiņš Clinical university Hospital Gatis Saknītis, Latvia
15:40–16:05	Are There Specific Changes in Microbial Composition in Patients with IgA Nephropathy? Anna Popova, Latvia
16:05–16:30	GdIgA+B Cell Differentiation in IgA Nephropathy Kristīne Oļeiņika, Latvia
16:30–16:50	Risk Factors for IgA Nephropathy Progression: Insights Beyond Galactose-Deficient IgA1 Levels Luīza Matuseviča, Latvia
16:50–17:00	Discussion, closing remarks

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #4 Committee: Inese Mihailova (Latvia), Prof. em. Harijs Čerņevskis (Latvia)
10:30–11:00	Diabetes Mellitus and Peritoneal Dialysis Associated Peritonitis Impact on Patients’ Five-Year Survival Anna Jana Saulīte, Latvia
10:30–11:00	Implications of Early Contrasted with Planned Initiation of Peritoneal Dialysis Aļona Sakoviča, Latvia

28 March. Rare Diseases. Agenda

The Rare Disease Session will address the current challenges and advancements in rare disease research and management both in Latvia and globally. The session will conclude with a clinically focused discussion on selected rare disease case reports, providing practical insights for healthcare professionals.

Agenda

Session I: Rare Diseases in Paediatrics Chair: Madara Auzenbaha (Latvia)
9:00–9:30	Gene Therapy in Metabolic Diseases Nicola Brunetti-Pierri, Italy
9:30–9:40	Results of Newborn Screening for Biotinidase Deficiency Over a 5-Year Period: Genotype and Phenotype, Therapy, and Challenges Sabīne Laktiņa, Latvia
9:40–9:50	Implementation and Results of Severe Combined Immunodeficiency Screening in Latvia: April 2023 – September 2024 Marija Rozevska, Latvia
9:50–10:00	Severe Combined Immunodeficiency Newborn Screening in Ukraine: 2-Year Experience Anastasiia Bondarenko, Ukraine
10:00–10:10	Comprehensive Evaluation of Sleep-Disordered Breathing in Paediatric Neuromuscular Diseases: Insights from a Retrospective Cohort Study Tīna Luīze Čupāne, Latvia
10:10–10:20	Pediatric Hypertrophic Cardiomyopathy in Latvia and Sarcomeric Cardiomyopathy as the Most Common Cause of Primary Hypertrophic Cardiomyopathy: A 12-Year Review Elīna Ligere, Latvia
10:20–10:30	Teduglutide – A New Option for Management in Children with Short Bowel Syndrome Inita Kaže, Latvia
10:30–11:00	Break
Session II: Rare Diseases in Adults Chair: Valdis Ģībietis (Latvia), Andris Skride (Latvia)
11:00–11:20	New Horizons in Treatment of Pulmonary Arterial Hypertension Ričards Kauliņš, Latvia
11:20–11:40	Systemic Amyloidosis in Latvia 2020–2024 Valdis Ģībietis, Latvia
11:40–12:00	New Horizons in the Treatment of Hypertrophic Cardiomyopathy Irina Griķe, Latvia
12:00–12:20	10-Year Experience of the Rīga East Clinical University Hospital in the Treatment of Gastric Lymphoma Aļona Vikentjeva, Latvia
12:20–12:30	Discussion
12:30–13:30	Break
Session III: Genetics and Molecular Diagnostics of Rare Diseases Chair: Linda Gailīte (Latvia)
13:30–13:45	ORPHA Codes Usage from Rare Disease Registry Madara Auzenbaha, Latvia
13:45–14:00	Revisiting Lowe Syndrome: A Report on Atypical Phenotypic Expression linked to Hypomorphic Genetic Variant Sandra Ose, Latvia
14:00–14:15	Retrospective Analysis of Motor Neuron Disease: A Single-Centre Study on Diagnosis, Classification, and Genetic Insights Vladimirs Krutovs, Latvia
14:15–14:30	Clinical Phenotype of Paediatric Patients with a Recurrent Pathogenic Variant in the HESX1 Gene Agnese Gūtmane, Latvia
14:30–14:45	Analysis of Molecular Genetic Testing for Hereditary Forms of Cancer 2020–2024 Ilona Piruška, Latvia
14:45–15:00	Molecular Diagnostic Possibilities for Latvian Rare Disease Patients Inga Nartiša, Latvia
15:00–15:30	Break
Session IV: Rare Disease Case Reports Chair: Valdis Ģībietis (Latvia), Ainārs Rudzītis (Latvia)
15:30–15:40	AL Amyloidosis with Peritoneal Involvement and Refractory Ascites: A Case Report Valdis Ģībietis, Latvia
15:40–15:50	Azithromycin and Mycoplasma Pneumonia: An Unusual Stevens-Johnson Syndrome Case Pauls Bērziņš, Latvia
15:50–16:00	Chronic Osteomyelitis in a Patient with Congenital Insensitivity to Pain with Anhidrosis Liena Gasiņa, Latvia
16:00–16:10	Paroxysmal Non-Kinesigenic Dyskinesia in a Paediatric Patient: A Case Report Monta Dāniele, Latvia
16:10–16:20	Takotsubo Cardiomyopathy Induced Heart Septum Rupture: A Case Report Viktorija Panova, Latvia
16:20–16:30	Acute v.renalis Thrombosis as Nutcracker Syndrome Complication Valdis Dakuļs, Latvia
16:30–16:40	Neuroendocrine Tumor of the Liver? Sofija Viļisova, Latvia
16:40–16:50	A Case Report of Invasive Aspergillosis and Brain Toxoplasmosis in Patient with Immune Supression Emīls Talačka, Latvia
16:50–17:00	Discussion Valdis Ģībietis, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #4 Committee: Assoc. Prof. Madara Auzenbaha (Latvia)
10:30–10:40	Glutaric Acidemia Type I: An Atypical Presentation with Visual Disturbances After Mild Head Trauma in a Paediatric Patient Sandis Kovaļovs, Latvia
10:40–10:50	Congenital LQTS – Clinical Practice in Children’s Clinical University Hospital of Latvia Diāna Stoldere, Latvia
10:50–11:00	Anti-Lgi1 Encephalitis in a Paediatric Patient: A Case Report Marija Luīze Kalniņa, Latvia
Committee: Linda Gailīte (Latvia), Valdis Ģībietis (Latvia)
12:50–13:00	Serum Metabolomic Profiling in Systemic Sclerosis Uncovers Potential Biomarkers Kristīne Ivanova, Latvia (Moved to 26 March, Screen #6 13:20-13:27)
13:00–13:10	A Comparative Evaluation of Genetic and Classical Testing for Epidermolysis Bullosa Adelia Bulicanu, Moldova

Keynote Speakers

Oncology and Hematology – Biomarker-Driven Precision Medicine

Mirjam Blattner-Johnson

Hopp Children's Cancer Center Heidelberg, Germany

MD, PhD Arcangela De Nicolo

Institute of Oncology and Molecular Genetics, Rīga Stradiņš University

Prof. Jacek Gronwald

Pomeranian Medical University, Poland

Transforming Care: Treatment Quality Improvement in Kidney Disease and Beyond

Prof. Kitty Jager

Amsterdam University Medical Center, Netherlands

Assoc. Prof. Vianda Stel

Amsterdam University Medical Center, Netherlands

Prof. Alberto Ortiz

Autonomous University of Madrid, Spain

Assoc. Prof. Sabine Leh

University of Bergen, Norway

Scientific Committee

Oncology and Hematology – Biomarker-Driven Precision Medicine

• Prof. Arvīds Irmejs, Institute of Oncology and Molecular Genetics, Rīga Stradiņš University
• Prof. Zanda Daneberga, Institute of Oncology and Molecular Genetics, Rīga Stradiņš University
• Prof. Jānis Gardovskis, Department of Surgery, Faculty of Medicine, Rīga Stradiņš University
• Prof. Sandra Lejniece, Dean, Department of Doctoral Studies / Department of Internal Diseases, Rīga Stradiņš University
• Prof. Edvīns Miklaševičs, Faculty of Medicine, Department of Biology and Microbiology, Rīga Stradiņš University

Transforming Care: Treatment Quality Improvement in Kidney Disease and Beyond

• Prof. Alberto Ortiz, MD, PhD, Autonomous University of Madrid, Spain; Chief of Nephrology and Hypertension at Fundacion Jimenez Diaz University Hospital and Health Research Insitute (IIS-FJD UAM), Madrid, Spain 
• Prof. Kitty J. Jager, MD, PhD, Department of Medical Informatics at Amsterdam University Medical Center, Netherlands
• Assoc. Prof. and Principal Investigator Vianda S. Stel PhD, Department of Medical Informatics at Amsterdam University Medical Center, Netherlands; European Renal Association Registry Managing Director
• Assoc. Prof. Sabine Leh, MD, PhD, Department of Clinical Medicine, University of Bergen; Department of Pathology, Haukeland University Hospital; Registry pathologist, Norwegian Renal Registry.
• Prof. Aivars Pētersons, MD, PhD, Department of Internal Diseases, Rīga Stradiņš University; Nephrology Centre, Pauls Stradins Clinical University Hospital
• Assoc. Prof. Viktorija Kuzema, MD, PhD, Department of Internal Diseases, Rīga Stradiņš University; Nephrology Centre, Pauls Stradins Clinical University Hospital; Head of Latvian Kidney Replacement Therapy Patient Registry
• Assist. prof. Kristīne Oļeinika, PhD, Department of Internal Diseases, Rīga Stradiņš University; Postdoctoral Research Fellow, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
• Assist. Prof. Kārlis Rācenis, MD, PhD, Department of Biology and Microbiology, Department of Internal Diseases, Rīga Stradiņš University; Nephrology Centre, Pauls Stradins Clinical University Hospital

Rare Diseases

• Assoc. Prof. Andris Skride, Rīga Stradiņš University
• Assoc. Prof. Madara Auzenbaha, Rīga Stradiņš University
• Dr. med. Linda Gailīte, Rīga Stradiņš University
• Assoc. Prof. Ainārs Rudzītis, Rīga Stradiņš University
• Prof. Aivars Lejnieks, Rīga Stradiņš University
• Dr. Valdis Ģībietis, Rīga Stradiņš University

Main Topics

Oncology and Hematology – Biomarker-Driven Precision Medicine

• Oncology
• Hematology
• Coagulation and Hemostasis 

Transforming Care: Treatment Quality Improvement in Kidney Disease and Beyond  

• IgA nephropathy 
• Immunology in renal diseases
• B cell immunity
• Surveillance of chronic kidney disease 
• Kidney disease registries
• Renal replacement therapy (hemodialysis, peritoneal dialysis, kidney transplantation) 
• Predialysis program

Rare Diseases

• Epidemiology and Natural History of Rare Diseases
• Diagnostic Challenges and Advances in Rare Diseases
• Innovative Therapies and Treatments for Rare Diseases
• Regulatory and Policy Issues in Rare Disease Research and Treatment
• Rare Disease Case Reports

Metabolism and Cardiovascular Diseases

26–27 March, Room 204, RSU, 21 Konsula iela

26 March. Arrhythmias, Cardiomyopathies, Invasive Cardiology, Cardiac Surgery. Agenda

The session will address emerging therapies and current research in the field of cardiac arrhythmias, sports medicine, cardiomyopathies, interventional cardiology and cardiac surgery. Among the best selected abstracts there will be state-of-the-art lectures presented by local and international faculty.

Agenda

Session I: Metabolism and Cardiovascular Diseases Chair: Prof. Aivars Lejnieks (Latvia), Prof. Ilze Konrāde (Latvia)
9:00–9:05	Introduction to the Session Ilze Konrāde, Latvia
9:05–9:25	HMG-CoA Reductase: From Statins Till Energy Metabolism Pathways Maija Dambrova, Latvia
9:25–9:45	Radiological Techniques for Quantifying Liver Steatosis and Fibrosis Maija Radziņa, Latvia
9:45–9:55	Alterations in Gastric Microbiota and Biochemical Markers in Autoimmune Atrophic Gastritis and Gastric Neuroendocrine Tumors Justīne Kaupe, Latvia
9:55–10:05	Predisposing Factors and Treatment Challenges in Diabetic Ketoacidosis: Insights from a Single Centre Data Inga Orleāne, Latvia
10:05–10:15	Shifted Energy Metabolism Towards Oxidation of Fatty Acids and Lower Physical Activity in Preclinical Model of HFpEF Reinis Vilšķērsts, Latvia
10:15–10:30	Q&A Session
10:30–11:00	Break
Session II: Sports Medicine / Arrhythmology / Genetics Chair: Prof. Oskars Kalējs (Latvia), Asst. Prof. Kristīne Jubele (Latvia)
11:00–11:05	Introduction to the Session Oskars Kalējs, Latvia
11:05–11:25	Athlete's Heart and Risk of Arrhythmias? Oskars Kalējs, Latvia
11:25–11:45	Cardiovascular Test Results in Latvian Basketball Veterans Ketija Apsīte, Latvia
11:45–12:05	Catheter Ablation as a Method of Choice in the Treatment of Atrial Fibrillation Kristīne Jubele, Latvia
12:05–12:17	Quality of Life in Patients with Atrial Fibrillation Undergoing Pulmonary Vein Isolation: Short Term Follow-up Study Matīss Linde, Latvia
12:17–12:30	Extrasystole Prevalence Among Master Basketball Players Ketija Apsīte, Latvia
12:30–13:30	Break
Session III: Cardiomyopathies / Interventional Cardiology Chair: Assoc. Prof. Andris Skride (Latvia), Assoc. Prof. Ainārs Rudzītis (Latvia)
13:30–13:35	Introduction to the Session Andris Skride, Latvia
13:35–14:10	Treatable Metabolic Cardiomyopathies Aleš Linhart, Czechia
14:10–14:20	BPA in Treatment of CTEPH (Latvian PH Registry Data) Andris Skride, Latvia
14:20–14:30	The Role of Genetic Variants Pathogenesis and Clinical Outcomes of Atrial Fibrillation Irina Griķe, Latvia
14:30–14:40	The Role of PFO Closure in the Treatment of Migraine Agnete Teivāne, Latvia
14:40–14:50	Chemotherapy-Induced Cardiac 18F-FDG Uptake in Lymphoma Patients: An Early Metabolic Indicator of Cardiotoxicity? Marika Kalniņa, Latvia
14:50–15:00	Q&A Session
15:00–15:30	Break
Session IV: Contemporary Treatment of Heart Valve Diseases and Beyond Chair: Prof. Pēteris Stradiņš (Latvia), Assoc. Prof. Mārtiņš Kalējs (Latvia)
15:30–15:35	Introduction to the Session
15:35–15:55	Surgically Implantable Prosthetic Heart Valves in the TAVI Era Pēteris Stradiņš, Latvia
15:55–16:15	The Transaxillary Concept for Minimally Invasive Cardiac Surgery Manuel Wilbring, Germany
16:20–16:35	A Progress Report on Transcatheter Heart Valve Therapies in Latvia Mārtiņš Ērglis, Latvia
16:35–16:50	Aortic Adverse Event Risk Calculator: A Latvian Innovation at Your Fingertips Ivars Brečs, Latvia
16:50–17:00	Final remarks

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #6 Committee: Prof. Ilze Konrāde (Latvia), Prof. Maija Dambrova (Latvia)
10:30–10:40	Assessing Serum Acylcarnitine Profiles During Mixed Meal Test: A Novel Approach for Diagnosis of Diabetes Mellitus and Prediabetes Artūrs Pētersons, Latvia
10:40–10:50	Abnormal Thyroid Function in Adult Latvian Population: Single Laboratory Data Sergey Nikulshin, Latvia
10:50–11:00	Bioavailability and Distribution of Acetylcarnitine in Mice and Healthy Volunteers Kristaps Krims-Dāvis, Latvia

27 March. Integrative Biomarker-Based Prevention of Cardiovascular and Metabolic Diseases, Personalized Therapy, and Identification of Drug Targets. Agenda

Biomedicine is recognised as one of the priorities for national research investments according to the Smart Specialization Strategy for Research and Innovation. For implementing this strategy an ambitious and unique project was carried out in 2023-2024 – State research project in the field of biomedicine, medical technologies and pharmacy.

Learn more about the project

The mission statement of this Project is: improving access to treatment for reduction of mortality or morbidity rates and improved health conditions through the development of medicinal products and their manufacturing technologies, transport forms and vaccines, repurposing of marketed drugs, the drug discovery and development, as well as the identification of new biomarkers and the development of a precision medical solution.

The implementation of the Project was performed in separate work packages (WP) by collaborative efforts of the consortium partners. The WP2, 'Integrative biomarker-based prevention of cardiovascular and metabolic diseases, personalized therapy, and identification of drug targets,' aims to create new techniques and methods of personalized monitoring, diagnostic and treatment, aiming to promote implementation of the latest scientific discoveries and modern technologies into a clinical practice to improve survival and quality of life of Latvian population.

This project combine clinical medicine competencies of University of Latvia (cardiovascular medicine) and Rīga Stradiņš University (metabolic diseases and neonatal medicine) with preclinical pharmacology expertise of the Latvian Institute of Organic Synthesis and molecular biology research achievements of Latvian Biomedical Research and Study Centre.

The following tasks were implemented during the project:

1. direct diagnostic accuracy comparison of intravascular ultrasound (IVUS), optical coherence tomography (OCT) and near infrared spectrometry (NIRS) for the detection and characterization of coronary plaque composition, including determination of atherosclerotic plaque rupture risk by positron emission tomography (PET/CT); 
2. evaluation of the expression of atherosclerosis related microRNAs and their correlation with unfavorable atherosclerotic plaque characteristics. 
3. evaluation of the effect of statins on acylcarnitine metabolism as a possible mechanism of statin associated myopathy (SAM); 
4. optimization of triple hormone administration to maximize weight loss, increase resting metabolic rate and to control blood glucose.
5. search for new, sensitive prognostic biomarkers that can be implemented in clinical practice for the development of non-invasive testing algorithms for the early diagnosis, evaluation, and prognosis of life-threatening diseases in newborns. 
6. investigation of the opportunities to increase omega-3 PUFA content by inhibition of their metabolism; 
7. selection of anti-sense oligonucleotide candidates for the treatment of the calpainopathy. 

Today's conference is dedicated to the results of the above-mentioned research included in the WP2 package, their analysis and the perspective of further research.

(Integratīva biomarķieros balstīta kardiovaskulāro un metabolo slimību prevencija, personalizēta terapija un zāļu mērķu identificēšana) – Ekonomikas ministrijas VPP-EM-BIOMEDICĪNA

Agenda

Session I Chair: Prof. Aivars Lejnieks (Latvia), Prof. Andrejs Ērglis, Dr. med. Vilnis Dzērve (Latvia), Prof. Ilze Konrāde (Latvia)
9:00–10:30	Evaluation and Current Status of Intravascular Imaging and Functional Assessment in Coronary Artery Disease Sanda Jēgere, Andrejs Ērglis, Vilnis Dzērve, Latvia
	Evaluation of the Expression of Atherosclerosis Related MicroRNAs and Their Correlation with Unfavorable Atherosclerotic Plaque Characteristics Evija Kanašniece, Kārlis Trušinskis, Latvia
	Intravascular Ultrasound (IVUS) and Near Infrared Spectrometry (NIRS) for the Detection of Rupture-Prone Atherosclerotic Plaque Baiba Kokina, Māris Lapšovs, Kārlis Trušinskis, Andrejs Ērglis, Latvia
10:30–11:00	Break
Session II Chair: Prof. Aivars Lejnieks (Latvia), Prof. Andrejs Ērglis, Dr. med. Vilnis Dzērve (Latvia), Prof. Ilze Konrāde (Latvia)
11:00–12:30	Targeting PUFA Mitochondrial Metabolism: A Novel Strategy to Enhance PUFA Levels for Therapeutic Benefit Ilze Konrāde, Baiba Gukālova, Artūrs Pētersons, Maija Dambrova, Latvia
	Development of Specific Biomarkers and Candidate Molecules for the Treatment of Statin-Associated Myopathy (SAM) Eva Bolšteina, Edgars Liepiņš, Marta Anna Ozoliņa, Gustavs Latkovskis, Maija Dambrova, Latvia
	New Approach to Multiple Hormone Therapy to Maximize Body Weight Loss, Increase Resting Metabolic Rate and Better Control the Blood Glucose Valdis Pīrāgs, Svjatoslavs Kistkins, Dmitrijs Bļizņuks, Latvia
12:30–13:30	Break
Session III Chair: Prof. Aivars Lejnieks (Latvia), Prof. Andrejs Ērglis, Dr. med. Vilnis Dzērve (Latvia), Prof. Ilze Konrāde (Latvia)
13:30–15:00	On the Road to Personalized Therapy for the Treatment of Inherited Muscular Dystrophy Karīna Goluba, Jānis Stāvusis, Inna Inaškina, Anastasija Tvornoviča, Vadims Parfejevs, Baiba Lāce, Una Riekstiņa, Latvia
	Minimally Invasive Diagnostic and Prognostic Biomarkers in Neonates with Necrotizing Enterocolitis: Case Series of Single Centre Experience Jānis Karlsons, Zanda Daneberga, Juta Kroiča, Edvīns Miklaševičs, Miki Nakazawa-Miklaševiča, Elza Elizabete Liepiņa, Renārs Broks, Ingus Skadiņš, Dace Gardovska, Lāsma Asare, Anete Rozentālberga, Zane Ābola, Latvia
	Neonatal Urinary Metabolomics in Sepsis Prof. Kristaps Kļaviņš, Zanda Daneberga, Theresa Schiemer, Jingzhi Fan, Julia Kapzems, Annija Vaska, Diāna Dakica, Dace Gardovska, Latvia
15:00–15:30	Break
Session IV Chair: Prof. Aivars Lejnieks (Latvia), Prof. Andrejs Ērglis, Dr. med. Vilnis Dzērve (Latvia), Prof. Ilze Konrāde (Latvia)
15:30–17:00	Perspectives of the National Research Programme (NRP) – Creation of a Research Platform and Problems Osvalds Pugovičs, Latvia
	Discussion (all lecturers)

Keynote Speakers

Prof. Manuel Wilbring

Heart Center Dresden University Hospital

Prof. Aleš Linhart

Charles University, Czech Republic

Scientific Committee

• Prof. Aivars Lejnieks MD, PhD, Department of Internal Diseases, Riga Stradin’s University, Riga East University Hospital 
• Prof. Ilze Konrāde MD, PhD, Department of Internal Diseases, Riga Stradin’s University, Riga East University Hospital
• Maija Dambrova, Dr. pharm. Professor in the Department of Pharmaceutical Chemistry, Riga Stradins University; Head of Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis; Full Member of the Latvian Academy of Sciences
• Prof. Dace Gardovska MD, PhD, Department of Pediatrics, Riga Stradin’s University, Riga East University Hospital
• Prof. Oskars Kalējs, Rīga Stradiņš University
• Prof. Pēteris Stradiņš, Rīga Stradiņš University
• Dr. med. Mārtiņš Kalējs, Rīga Stradiņš University
• Assoc. Prof. Andris Skride, Rīga Stradiņš University
• Assoc. Prof. Ainārs Rudzītis, Rīga Stradiņš University
• Prof. Maija Radziņa, Rīga Stradiņš University
• Prof. Aleš Linhart, Charles University in Prague, Czech Republic
• Dr. med. Manuel Wilbring, Dresden University Hospital, Germany
• Prof. Andrejs Ērglis MD, PhD, Faculty of Medicine and Life Sciences, University of Latvia, Paula Stradin’s Clinical University Hospital 
• Vilnis Dzērve MD, PhD, Faculty of Medicine and Life Sciences, University of Latvia
• Osvalds Pugovics Dr. chem., Latvian Institute of Organic Synthesis
• Edgars Liepiņš, Dr. pharm., Principal Scientist at the Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis; Full Member of the Latvian Academy of Sciences

Main Topics

• Metabolism and cardiovascular diseases
• Arrhythmology
• Genetics in cardiology
• Cardiomyopathies
• Interventional cardiology
• Cardiac surgery

Sport Science, Sport Medicine and Rehabilitation

26–27 March, Auditorium #2, RSU, 16 Dzirciema iela

26 March. Agenda

Session I: Advances in Sports Technology Chair: Guna Semjonova (Latvia), Jānis Lungevičs (Latvia)
9:00–9:15	Overview of Experimental Setups for Ice Friction Testing Jānis Lungevičs, Latvia
9:15–9:30	Sesnor System for Monitoring Technical Sports Leo Seļāvo, Latvia
9:30–9:45	Study of Static and Dynamic Mechanical Properties of Wood Fiber Composites for Technical Sports Applications Andrejs Pupurs, Latvia
9:45–10:00	Sports Aerodynamics: Computational and Experimental Fluid Dynamics (CEFD) Based Technologies for Improved Performance Ali Arshad, Latvia
10:00–10:15	Assessment of Lower Limb Biomechanics Using Wearable Sensors in Youth Football Players Executing Single Leg Squat Anna Davidoviča, Latvia
10:15–10:30	Toward a Framework of Visuo Spatial Measurements in Sports Santa Bartušēvica, Latvia
10:30–11:00	Break
Session II: Training Methods and Protocols Chair: Normunds Vārpa (Latvia), Assoc. Prof. Amelia Guadalupe Grau (Spain)
11:00–11:30	Optimizing Resistance Training for Cardiovascular Health: A Comprehensive Approach Amelia Guadalupe Grau, Italy
11:30–11:45	Exploring Inter-Limb Asymmetry: Preliminary Insights on Variability Across Assessment Protocols and Potentional Applications for Training Program Design Zane Šmite, Latvia
11:45–12:00	Muscle Strength and Range of Motion in Youth Athletes: Implications for Injury Prevention Luisa Dombrovska, Latvia
12:00–12:15	Balance Performance Influencing Factors and their Trainability in Athletes Inese Pontaga, Latvia
12:15–12:30	Effects of Step Frequency Manipulation on Running Stability and Kinematics with Auditory and Visual Feedback Edgars Bernāns, Latvia
12:30–13:30	Break
Plenary Session: Limitations of Performance Chair: Assoc. Prof. Amelia Guadalupe Grau (Spain), Asst. Prof. Dace Reihmane (Latvia)
13:30–14:00	Cardiovascular Limitations to Performance in Sport: Effects of Age, Sex, and Training Jostein Hallén, Norway
14:00–14:30	Mental Fatigue in Sports: from the Lab to the Field Bart Roelands, Belgium
14:30–14:45	Ultra Endurance Velo Race Induces 10-Fold Increase in Serum FGF-21 Levels Dace Reihmane, Latvia
14:45–15:00	Maximal Oxygen Consumption (VO2 max) Determination Options for Master Basketball Players with the Astranda Cycle Ergometry Test, the YMCA Cycle Ergometry Test, and the Polar OWNindex Test Signe Tomsone, Latvia
15:00–15:30	Break
Session IV: Exercise and Physical Health Chair: Jostein Hallén (Norway), Bart Roelands (Belgium)
15:30–15:45	Effects of Acute Exercise on IL-6, M-CSF, IL-27, MIG/CXCL9, EGF, AND sCD40L Biomarkers Profile in Breast Cancer Patients Kristiāna Kovtuna, Latvia
15:45–16:00	Effect of Acute Exercise on Serum Myokine Levels in Breast Cancer Survivors Linda Laizāne, Latvia
16:00–16:15	Incidence of Vitamin D and Iron Deficiency in Youth Athletes in Latvia (IMRSports) Ilze Justamente, Latvia
16:15–16:30	Cardiorespiratory Fitness and Body Mass Index Predicts Variation of Metabolic Syndrome Criteria in Schoolchildren (PACH Study) Jeļena Raudeniece, Latvia
16:30–16:45	Effect of Acute Ultra Endurance Exercise on Serum FGF-18 Levels Ilze Barone, Latvia
16:45–17:00	Self-Efficacy, Perceived Stress, Physical Activities and Sleep Quality of Sport Educators Andra Fernāte, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #3 Committee: Aija Kļaviņa (Latvia), Assoc. Prof. Signe Tomsone (Latvia)
10:30–10:37	Effect of Schultz's Autogenic Training to Reduce Fatigue in Basketball Players Peter Kutiš, Slovakia
10:37–10:44	Effect of Different Teaching Methods on The Acquisition of Front Crawl in Healthy Children with Residual Primitive Reflexes Irina Bogdanoviča, Latvia
Committee: Asst. Prof. Una Veseta (Latvia), Prof. Anda Fernāte (Latvia)
12:30–12:37
12:37–12:44	Breathing Techniques for the Enhancement of Cognitive Function and Stress Reduction in 14–17 Year-Old Adolescent Athletes: A Scoping Review Gints Peleckis, Latvia
12:44–12:51	Effects of Eight-Week Training with Core Exercises on Core and Pelvis Muscle Strength Balance in Adulthood Male Soccer Players Laura Žalienė, Lithuania
12:51–12:58	Analysis on the Physical Characteristics of Functional Mobility, Trunk and Shoulder Girdle Muscle Strength Balance in Young Sailors Laura Žalienė, Lithuania
12:58–13:05	Prevalence and Risk Factors of Pedes Plani Deformity in Preschool Children Lenka Ondrušková, Slovakia
Committee: Asst. Prof. Renārs Līcis (Latvia), Assoc. Prof. Kalvis Ciekurs (Latvia)
13:05–13:12	Motivation of Latvian Junior Athletes to Engage in Powerlifting Irēna Upeniece, Latvia
13:12–13:19	Parental Support in Competitive Youth Hockey Rodrigo Laviņš, Latvia
13:19–13:26	Tendencies in the Use of Game Zones and the Effectiveness of Players’ Actions in Different Game Formats in the U13 Age Group Imants Bleidelis, Latvia
Committee: Asst. Prof. Dace Reihmane (Latvia), Prof. Inga Millere (Latvia)
15:00–15:07	Polygenic Profile of PPARs Genes Family in Elite Athletes Valentina Ginevičienė, Lithuania
15:07–15:14	Aute Effects of Beetroot Juice Supplementation on Aerobic Performance in Endurance Athletes: A Randomized Controlled Trial Jekaterina Neteča, Latvia
15:14–15:21	Meldonium – an Old Drug as a Novel Challenge for Sport Medicine Alexandru Timerican, Moldova

27 March. Agenda

Session I: Exercise and Mental Health Chair: Kristīne Šneidere (Latvia), Gundega Ulme (Latvia)
9:00–9:15	Problematic Internet Use Relationship with Cognitive and Physical abilities in Adolescents Participating in Extracurricular Sports Rizky Nurulfa, Latvia
9:15–9:30	Maximal Oxygen Uptake (VO2 max) Is Not Associated with Depressive Symptoms and Working Memory Performance in Master Basketball Players Laima Dance, Latvia
9:30–9:45	A Comparative Analysis of Psychological Skills: Athlete and Psychologist Perspectives Across Different Performance Levels Katrīna Volgemute, Latvia
9:45–10:00	Integrated Learning of Fundamental Movements and Values through Judo-Philosophy-Based Physical Activities Jekaterina Krauze, Latvia
10:00–10:15	Investigating Preschoolers' Emotional Responses to Outdoor Activities Using FaceReader Behnam Boobani, Latvia
10:15–10:30	Effect of Outdoor Activities on Stress Levels and Emotional Well-Being on Young People Laura Anspuka, Latvia
10:30–11:00	Break
Session II: Sports Medicine Chair: Sandra Rozenštoka (Latvia), Prof. Yannis Pitsiladis (Hong Kong)
11:00–11:30	Mental health conditions in Elite Athletes: early detection and effective actions. The role of sports medicine Fabio Pigozzi, Italy
11:30–12:00	High Achievement Sports Genetics and Sports Medicine Yannis Pitsiladis, Hong Kong
12:00–12:15	Challenges in the Elite Para Athlete Medical Care Sandra Rozenštoka, Latvia
12:15–12:23	Evaluating the Efficacy of Systematic Screening in Master Basketball Players: Insights into Cardiovascular Risk Detection and Overall Health Improvements Ketija Apsīte, Latvia
12:23–12:30	Assessment of Correlation between Dynamic Balance, Flexibility of Ankle Joints, and Shin Muscles Peak Isometric Strength in Adolescent Football Players Andrew Rinaldi Sinulingga, Latvia
12:30–13:30	Break
Session III: Rehabilitation and Adaptive Sports Chair: Assoc. Prof. Signe Tomsone (Latvia), Aija Kļaviņa (Latvia)
13:30–14:00	Measurement System for Biomechanics, Both for Sport and Rehabilitation Matteo Lancini, Italy
14:00–14:15	From Youth to Aging: The Relationship Between Motor Reserves and Mental Health in Masters Basketball Players Zane Ulmane, Latvia
14:15–14:30	Assessment of Physical Fitness in Children with Disabilities in Latvia Aija Kļaviņa, Latvia
14:30–14:40	Cardiopulmonary Exercise Test Outcomes of Athletes with Disability in Latvia Gundega Akuratere, Latvia
14:40–14:50	Physical Performance, Daily Physical Activity, Autonomy and Participation in Head and Neck Cancer Survivors Living with Tracheostomy Tube Marta Marija Maltisova, Latvia
14:50–15:00	Remote Assessment of Upper Extremity Functions: Solution for Military Rehabilitation Professionals in Ukraine Aija Kļaviņa, Latvia
15:00–15:30	Break
Session IV: Sports Management: Infrastructure, Economics, Ethics and Rights Chair: Assoc. Prof. Karina Palkova (Latvia), Renārs Līcis (Latvia)
15:30–16:00	Children’s Rights in Sport Susanna Hedenborg, Sweden
16:00–16:15	Bibliometric Analysis of the Peer-Reviewed Literature of Sport Impact on the Economy Marina Kudinska, Latvia
16:15–16:30	The Branding Model of the Latvian Higher Football League Based on the Customers' Wishes Aleksandrs Iļjins, Latvia
16:30–16:45	Athletic Career Transition Strategies in Football Atis Kovaļovs, Latvia
16:45–17:00	Indicators that Characterize Development of Sports in Latvia: A Pilot Study in Municipalities Andra Fernāte, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #3 Committee: Aija Kļaviņa (Latvia), Assoc. Prof. Signe Tomsone (Latvia)
10:30–10:37	Effects of Breathing Exercises on Young Swimmers’ Respiratory System Parameters and Performance Germans Jakubovskis, Latvia
10:37–10:44	Persistence of Residual Primitive Reflexes during the Acquisition of Swimming Strokes in Healthy Children Irina Bogdanoviča, Latvia
11:44–11:51	Swimmers' Shoulder Injury Prevention by Testing at a Young Age Jeļena Solovjova, Latvia
Committee: Asst. Prof. Renārs Līcis (Latvia), Sandra Rozenštoka (Latvia)
12:30–12:37	The Relationship Between Maximal Oxygen Uptake (VO2 max) and Body Composition Indicators in Master Basketball Players Una Veseta, Latvia
12:37–12:44	Methodology for the Determination of Maximal Oxygen Consumption (VO2 max) by Incremental Exercise Cycle Ergometry Test in Master Basketball Players Signe Tomsone, Latvia
12:44–12:51	Gas Exchange Kinetics in Cross-Country Skiers Executing Repeated Dynamic High Intensity Intervals Mārcis Jakovičs, Latvia
12:51–12:58	The Importance of Early Aerobic Intervention for Improving Functional Capacity in Patients after Cardiac Surgery in the Acute Phase Zinaida Griščenko, Latvia
Committee: Asst. Prof. Una Veseta (Latvia), Assoc. Prof. Kalvis Ciekurs (Latvia)
12:58–13:05	Transcutaneous Electrical Nerve Stimulation (TENS) Application for Spasticity Reduction in Lower Extremity Muscles in Individuals with Spinal Cord Injury Dace Stirāne, Latvia
13:05–13:12	Subjective Aspects in the Assessment of Patient Self-Correction S-Shaped Idiopathic Scoliosis Patients Aivars Vētra, Latvia
13:12–13:19	Scar as a Possible Cause of Reduced Mobility Ivana Aštaryová, Slovakia
13:19–13:26	Monitoring Stress and Recovery: A Preliminary Latvian Version of the Recovery-Stress Questionnaire (RESTQ-Sport) Behnam Boobani, Latvia

28 March. Side event

Discussion: "The Young Athlete in Latvia: How Sustainable is Our System?" (in Latvian)

Keynote speakers

Prof. Susanna Hedenborg

Malmö University, Sweden

Prof. Jostein Hallén

Norwegian School of Sport Sciences

Prof. Bart Roelands

Vrije Universiteit Brussel, Belgium

Matteo Lancini

Mechanical and Thermal Measurement Laboratory of the University of Brescia, Italy

Prof. Yannis Pitsiladis

University of Brighton, UK

Assoc. Prof. Amelia Guadalupe Grau

University of Castilla-La Mancha, Spain

Prof. Fabio Pigozzi

University of Rome “Foro Italico”, Italy

Scientific Committee

• Prof. Inga Millere, Dean, Faculty of health and Sport Sciences, Rīga Stradiņš University, Latvia
• Prof. Aija Kļaviņa, Lead researcher, Rīga Stradiņš University, Latvia
• Assoc. Prof. Signe Tomsone, Department of Rehabilitation, Rīga Stradiņš University, Latvia
• Assoc. Prof. Kalvis Ciekurs, Latvian Academy of Sport Education, Riga Stradiņš University, Latvia
• Asst. Prof. Dace Reihmane, Lead researcher, Laboratory of Sports and Nutrition Research, Rīga Stradiņš University, Latvia
• Dr Sandra Rozenštoka, Lead Researcher, Institute of Public Health,  Rīga Stradiņš University, Latvia
• Prof. Bart Roelands, Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit, Belgium
• Prof. Susanna Hedenborg, Professor of Sports Science and Associate Professor in Social and Economic History, Malmo University, Sweden
• Prof. Yannis Pitsiladis, The Chairman of Scientific committee of the European Federation of Sports Medicine Associations, Professor of Sport and Exercise Science, University of Brighton, United Kingdom
• Prof. Matteo Lancini, Mechanical and Thermal Measurement Laboratory, University of Brescia, Italy 
• Assoc. Prof. Amelia Guadalupe-Grau, Universidad de Castilla-la Manch, Spain
• Andra Fernāte, Rīga Stradiņš University Latvian Academy of Sport Education
• Renārs Līcis, Rīga Stradiņš University Latvian Academy of Sport Education
• Una Veseta, Rīga Stradiņš University

Main Topics

• Sport science
• Sport medicine
• Rehabilitation

Women`s and Children`s Health

26–27 March, Auditorium #1, RSU, 16 Dzirciema iela

26 March. Empowering Women’s Health, Bridging Gaps, Advancing Care. Agenda

The main topics of the section Empowering Women’s Health, Bridging Gaps, Advancing Care are dedicated to the challenges of modern sexual and reproductive medicine, obstetrics, and gynecology. Together with world-renowned experts, we will discuss current issues in pregnancy termination, evidence-based obstetric practice, success in eradicating cervical cancer, the importance of the quality of sexual life in a woman's health, and advances in ultrasonography.

Agenda

Session I: Challenges of Sexual and Reproductive Health in the 21st Century in Latvia and Beyond Chair: Prof. Gunta Lazdāne (Latvia), Prof. Kristina Gemzell Danielsson (Sweden)
9:00–9:20	Sex without Pain Gilbert Donders, Belgium
9:20–9:40	High Quality Abortion Care Kristina Gemzell Danielsson, Sweden
9:40–9:52	Understanding the Structure of Preterm Births in Latvia: A National Register-Based Study of Trends, Contributing Factors, and Public Health Implications Diāna Andžāne, Latvia
9:52–10:04	Evaluating Clinical Predictors of Pregnancy and Obstetric Outcomes in Singleton Pregnancies with Cervical Insufficiency Undergoing Cervical Cerclage and Expectant Treatment Valērija Rakša, Latvia
10:04–10:16	Pregnancy Outcomes in Kidney Transplant Recipients Ieva Ziediņa, Latvia
10:16–10:28	Biochemical Correlation Between Inhibin B and FSH in Spermatogenesis: Mechanisms, Pathways, and Regulatory Interactions Ecaterina Pavlocschi, Moldova
10:30–11:00	Break
Session II: Patient Experience as an Important Outcome Measure in Obstetrics Chair: Assoc. Prof. Anna Miskova (Latvia), Prof. Dace Rezeberga (Latvia)
11:00–11:15	Findings from the IMAgiNE EURO Study: Women’s Experiences of Respectful Maternity Care in Healthcare Facilities Across 22 Countries over 3.5 Years Marzia Lazzerini, Italy
11:15–11:22	Childbirth Associated Factors in Quality of Maternal Care Elizabete Ārgale, Latvia
11:22–11:29	After-Birth Associated Factors in Quality of Maternal Care Barbara Baranovska, Poland
11:29–11:36	Birth Rights Associated Factors in Quality of Maternal Care Alina Liepinaitienė, Lithuania
11:36–11:43	Mental Health Related Factors in Quality of Maternal Care Valērija Rakša, Latvia
11:43–11:55	Childbirth Experience Among Primiparous Women in Latvia Undergoing Labor Induction: Insights from the Short Quality from Patient's Perspective-Intrapartal (s-QPP-I) Questionnaire Beāte Sārta, Latvia
11:55–12:07	Childbirth Experience Among Primiparas and Multiparas with Spontaneous Vaginal Delivery Irisa Zīle Velika, Latvia
12:07–12:30	Discussion
12:30–13:30	Break
Session III: Vulvovaginal Health – Best Practices and Emerging Trends Chair: Assoc. Prof. Jana Žodžika (Latvia), Prof. Gilbert Donders (Belgium)
13:30–13:50	Ingredients of Vulvovaginal Health Gilbert Donders, Belgium
13:50–14:02	Comparison of Vaginal Microflora Before and After Loop Electro-Excisional Procedure – Preliminary Results Laura Lūse, Latvia
14:02–14:14	The Associated Risk Factors Among Women Attending Colposcopy Clinic with High-Grade Squamous Intraepithelial Lesions and Above (HSIL+) Natalija Bērza, Latvia
14:14–14:26	Analysis of the Latvian Human Papillomavirus Type 16 Isolate Whole-Genome Sequencing Data from Cervical Carcinomas within the Global Context of Publicly Available Complete HPV16 Genome Sequences Maria Isaguliants, Latvia
14:26–14:38	The Incidence and Types of Postoperative Complications of Simple, Radical Vulvectomies and Vulvectomies with Reconstruction Tsira Tolordava, Latvia
14:38–15:00	Discussion
15:00–15:30	Break
Session IV: The Evolving Role of Ultrasound in Women's Health Chair: Prof. Natālija Vedmedovska (Latvia), Antonia Testa (Italy)
15:30–16:00	Diagnosis and Management of Ovarian Tumours During Pregnancy Antonia Testa, Italy
16:00–16:12	The Role of Ultrasound in the Preoperative Diagnosis of Ovarian Tumors During Pregnancy: A Case Report of Dysgerminoma Alise Vinogradova, Latvia
16:12–16:24	The Ophthalmic Artery – Is It Possible in Our Setting? Natālija Vedmedovska, Latvia
16:24–16:36	Routine Third Trimester Ultrasound Nowadays Ieva Evelīna Štolcere, Latvia
16:36–16:48	Vasa Praevia: A 10-Year Retrospective Analysis at Rīga Maternity Hospital (2014–2024) Anna Ilva Sedliņa, Latvia
16:48–17:00	Approach to Transplacental Therapy of Pathological Fetal Tachycardias – Distinct Cases Inguna Lubaua, Latvia

Poster presentations

Venue: RSU Cafeteria, 16 Dzirciema iela

Screen #1 Committee: Asst. Maira Jansone (Latvia)
10:30–10:40	Comparison of Spontaneous Singleton Labour and Induced Singleton Labour Elizabeta Lohova-Matīsa, Latvia
10:40–10:50	Analysis of the Incidence of Histologically Confirmed Chorioamnionitis in Preterm Deliveries Before 34 Weeks of Gestation at Rīga Maternity Hospital in 2023 Līva Ķīse, Latvia
10:50-11:00	Clinical Insights into Agenesis of the Septum Pellucidum: A Case Report Natālija Vedmedovska, Latvia
Committee: Natālija Bērza (Latvia)
12:30–12:40	Impact of Interventions During Labour on Women’s Perception of Childbirth Experience Evaluated by the Childbirth Experience Questionnaire Maija Priedniece, Latvia
12:40–12:50	A Case of Acheiria After Conception with Donor Oocytes Jūlija Tarasova, Latvia
Committee: Olga Plisko (Latvia)
12:50–13:00	Cervical Cancer Screening Patterns Among HIV-Positive Women in Latvia Elvita Penka, Latvia
13:00–13:10	Two Years of Human Papillomavirus (HPV) Screening in National Microbiology Reference Laboratory of Latvia: Achievements and Results Anastasija Ņiftaļijeva, Latvia
13:10-13:20	A Case Report of Osteogenesis Imperfecta Type II-Rare Lethal Disorder Jūlija Tarasova, Latvia
Committee: Assoc. Prof. Jana Žodžika (Latvia)
15:00–15:10	Müllerian Adenosarcoma: A Case Report Ivana Kumičikova, Slovakia
15:10–15:20	The First Eight Months of the Patient Contribution and Collaboration to the Oncology Research Through Informed Consent in Rīga East University Hospital Ināra Kampenuse, Latvia
15:20–15:30	Approach to Transplacental Therapy of Pathological Fetal Tachycardias – Distinct Cases Natālija Vedmedovska, Latvia

27 March. Children and Infections – Forever Together, but the Dimension is Changing. Agenda

The comprehensive scientific programme of this section will give valuable insights into the latest advances of research and developments in paediatric infectious diseases combined with practice-changing updates in care of children with infections.

Participants of the section will have the opportunity to attend lectures given by leading researchers and practitioners in the pediatric infectious field. All the topics will be presented and discussed from multiple perspectives allowing each participant to gain knowledge. Results from extensive research of tick borne encephalitis (TBE) in Latvia as well as several EU Horizon 2020 projects which paved the way for the latest DIAMONDS project will be presented to demonstrate the long-term research process of developing a molecular test for the rapid diagnosis of serious infectious and inflammatory diseases using personalised gene signatures. Within the framework of these projects, findings from Emergency departments across Europe alongside national data from Latvia will be presented to bring research close to clinic. 

Furthermore, we encourage participants to share their research interests at the Poster section to interact with other colleagues, exchange ideas and foster new collaboration. We encourage to submit posters on the following topics:

• Paediatric infectious diseases
• Fever in children
• Tick borne encephalitis

You will have an opportunity to meet passionate researchers, network with colleagues with similar interests, gain cutting-edge knowledge with the ultimate and common aim to improve care for our children.

Agenda

Session I: Peadiatric Infectious Diseases – State-of-the-Art in the 21st Century Chair: Prof. Henriette Moll (Netherlands), Prof. Dace Zavadska (Latvia)
9:00–9:40	Viruses – only bad guys? Gerhard Dobler, Germany
9:45–10:25	Fever, Infectious Diseases and Diagnostic Approaches in the 21st Century Michael Levin, UK
10:30–11:00	Break
Session II: EU Horizon 2020 Projects PERFORM and DIAMONDS (2016–2025) Chair: Prof. Dace Gardovska (Latvia), Prof. Jana Pavāre (Latvia)
11:00–11:30	Personalised Molecular Signatures for Diagnosis of Infectious and Inflammatory Diseases: the PERFORM and DIAMONDS Results Myrsini Kaforou, UK
11:30–12:00	When is fever dangerous? The Role of New and Old Biomarkers at the Emergency Department Henriette Moll, The Netherlands
12:05–12:30	Upper Respiratory Tract / ENT and Flu-Like Infections in a Single Northern European Paediatric Emergency Department: a Comparative Study of 2017 and 2024 Flu Seasons Aleksandra Rudzāte, Latvia
12:30–13:30	Break
Session III: Tick-Borne Encephalitis Studies (2016–2025) Chair: Prof. Gerhard Dobler (Germany), Asst. Prof. Liene Čupāne (Latvia)
13:30–14:00	TBE in Latvia – Clinical Picture, Early and Long Term Sequelae Guntis Karelis, Latvia
14:00–14:25	TBE Prophylaxis – TBE Vaccine Effectiveness Studies Dace Zavadska, Latvia
14:30–15:00	Tick-Borne Encephalitis Vaccine Breakthroughs – New Insights in the Role of Antibodies in TBE Infection Gerhard Dobler, Germany
15:00–15:30	Break
Session IV: PhD Studies in Paediatric Infectious Diseases Chair: Prof. Ilze Grope (Latvia), Prof. Inguna Lubaua (Latvia)
15:30–15:55	Tick-borne encephalitis NS1 Antibody Research in Latvia and Its Clinical Relevance Zane Freimane, Latvia
15:55–16:20	Two-Year Outcomes of Multisystem Inflammatory Syndrome in Children (MIS-C): Findings from Tertiary Level Children’s Hospital Ieva Roģe-Gurecka, Latvia
16:20–16:50	Effect of Combination of Point-of-Care C-Reactive Protein Testing and Educational Training on Antibiotic Prescribing and Diagnostic Habits for Children Presenting with Acute Infections in General Practice Zane Līkopa, Latvia
16:50-17:00	Long-Term Evaluation of Laboratory Diagnosis in Lyme Neuroborreliosis: Antibody Index as a Key Marker of Intrathecal Antibody Synthesis in CSF and Serum Samples Ļubova Rohļina, Latvia

Poster presentations

Venue: RSU Cafeteria, 16 Dzirciema iela

Screen #1

Committee: Prof. Dace Gardovska (Latvia), Asst. Prof. Liene Čupāne (Latvia)
10:40–10:50	Factors Affecting Metabolic Control of Type 1 Diabetes in Children One Year After Diagnosis Lizete Braivo, Latvia
10:50–11:00	Child-Centred Therapy Method Approach to Reduce Behavioural Signs in Children with Attention Deficit Hyperactivity Disorder: Systematic Literature Review Signe Ķezbere, Latvia
Committee: Prof. Iveta Dzīvīte-Krišāne (Latvia), Prof. Inguna Lubaua (Latvia)
12:30–13:30	Prevalence of Purulent Complications of Acute Upper Respiratory Tract Infections Before and After COVID-19 Restrictions / Impact of the COVID-19 Pandemic on the Prevalence of Deep Throat Infections at the Children's Clinical University Hospital Estere Jansone, Latvia
12:30–13:30	The Effect of Dynamic Neuromuscular Stabilization on Muscle Activity in Palliative Care Children: A Study Protocol Laura Žalienė, Lithuania
12:30–13:30	Preliminary Data of Immune Modulator Assessment in Children with Long COVID-19 Annija Meiere, Latvia
12:30–13:30	Neonatal Urinary Metabolomics in Sepsis Dace Sniedze, Latvia
Committee: Asst. Dace Sniedze (Latvia), Asst. Prof. Liene Čupāne (Latvia)
15:00–15:30	Evaluation of the Use of Platelet-Rich Fibrin Membrane for Myringoplasty in Paediatric Patients Ligita Kupica, Latvia

Screen #2

Committee: Prof. Valda Staņēviča (Latvia), Asst. Inga Ziemele (Latvia)
10:40–10:50	Bordetella Pertussis Outbreak in Latvia, 2024 Gaļina Muzje, Latvia
10:50–11:00	Adenoid Microbiota: Comparing Healthy and Otitis Media-Affected Middle Ears in Children Using 16S rRNA Sequencing Oļegs Sokolovs Karijs, Moldova
Committee: Prof. Ilze Grope (Latvia), Asst. Prof. Zane Dāvidsone (Latvia)
12:30–13:30	Seroprevalence of Tick-Borne Encephalitis in Latvia, 2019–2022, Indicates a High Disease Risk Zane Freimane, Latvia
12:30–13:30	Evaluation of Antibiotic Regimens for Non-Complicated Acute Appendicitis in Children Timurs Zurmutaī, Latvia
12:30–13:30	Cerebrovascular Manifestations of Lyme Neuroborreliosis in Paediatric Patients from 2014 to 2024: A Single Centre Experience Marija Luīze Kalniņa, Latvia
12:30–13:30	Acute Appendicitis in Paediatric Patients with SARS-CoV-2 Delta and Omicron Variants Timurs Zurmutaī, Latvia
Committee: Asst. Anija Meiere (Latvia), Prof. Jana Pavāre (Latvia)
15:00–15:30	Antibiotic Prescription Patterns for Children with Febrile Upper and Lower Respiratory Tract Infections in a Single Northern European Paediatric Emergency Department During Influenza Seasons 2017 and 2024 Evija Fusa, Latvia

Keynote Speakers

Prof. Antonia Testa

Catholic University of Sacred Heart, Rome, Italy

Prof. Kristina Gemzell Danielsson

The Karolinska Institute, Sweden

Prof. Gilbert G.G. Donders

University of Antwerp, Belgium

Prof. Gerhard Dobler

University of Hohenheim, Germany

Prof. Henriëtte Moll

Erasmus MC – Sophia Children’s Hospital, The Netherlands

Scientific Committee

Empowering Women’s Health, Bridging Gaps, Advancing Care

• Prof. Dace Rezeberga, Head Department of Obstetrics and Gynaecology, Rīga Stradiņš University
• Prof. Gunta Lazdāne, Department of Obstetrics and Gynaecology, Institute of Public Health, Rīga Stradiņš University
• Prof. Kristina Gemzell Danielsson, Karolinska Institutet, Sweden
• Prof. Natālija Vedmedovska, Department of Obstetrics and Gynaecology, Rīga Stradiņš University
• Assoc. Prof. Anna Miskova, Department of Obstetrics and Gynaecology, Rīga Stradiņš University
• Assoc. Prof. Jana Žodžika, Department of Obstetrics and Gynaecology, Institute of Public Health, Rīga Stradiņš University

Children and Infections - Forever Together, but the Dimension is Changing

• Prof. Gerhard Dobler, Bundeswehr Institute of Microbiology, German National Consultant Laboratory for TBEV, Munich, Germany; Dept. of Tropical Medicine and Infectious Diseases, Ludwig-Maximilians-Universität, Munich, Germany; Dept. of Parasitology, University of Hohenheim, Stuttgart, Germany
• Prof. Henriette Moll, Erasmus MC – Sophia Children’s Hospital, The Netherlands
• Prof. Dace Zavadska, Rīga Stradiņš University
• Prof. Jana Pavāre, Rīga Stradiņš University

Main Topics

Children's health 

• Children and infections 
  • Pediatric infectious diseases 
  • Fever in children 
• Pediatrics 
• Neonatology  

Women's health

• Sexual and reproductive health and rights
• Pregnancy and delivery care 
• Gynecology
• Ultrasound in obstetrics and gynecology
• Infertility
• Gynecological oncology and cancer prevention

Innovative Dosage Forms and Drug Delivery Systems

27 March. Room 305, RSU, 21 Konsula iela 

27 March. Agenda

Session I: Pharmaceutical Science Chair: Prof. Dace Bandere (Latvia), Assoc. Prof. Baiba Mauriņa (Latvia)
9:00–10:00	Systems Pharmacology and Drug Repurposing for Retinal Degenerations Henri Leinonen, Finland
10:00–10:10	Ultrasound-Assisted Extracting of Phenolic Compounds from Sorbus aucuparia Berry Pomaces Renāte Teterovska, Latvia
10:10–10:20	Chemometrics Combined with Data Fusion – A Tool for Comprehensive Phytochemical Characterization of Anthocyanin-Rich Fruit Extracts Ance Bārzdiņa, Latvia
10:20–10:30	Phenolic Compound and Antioxidant Activity Evaluation for Air-Dried Monarda didyma L. Leaves Using Two Extraction Methods and Solvents Līga Prieciņa, Latvia
10:30–11:00	Break
Session II: Drug Delivery Systems Chair: Asst. Prof. Agnese Brangule (Latvia), Konstantīns Logviss (Latvia)
11:00–11:15	Enhancing Tissue Engineering Through Liposomes Containing Bioactive Molecules Inga Jurgelāne, Latvia
11:15–11:30	Comparing Polymer Drug Loading Methods and Solubility Parameters Artūrs Paulausks, Latvia
11:30–11:45	Development of Size Exclusion Chromatography-Based Method for Analysis of Pharmacokinetics and Biodistribution of Nanoparticles Antons Sizovs, Latvia
11:45–12:00	Surrogate Models in Pharmaceutical Dissolution Testing: A Case Study Sabīne Upnere, Latvia
12:00–12:15	Development of Hypoallergenic Cream Based on Natural Oils and Hydrogenated Phosphatidylcholine Beāta Denisa, Latvia
12:15–12:30	New Light-Activated Styrylpyridinium Compounds for Cancer Treatment Using Photodynamic Therapy Reinis Putrālis, Latvia
12:30–13:30	Break

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #7 Committee: Prof. Dace Bandere (Latvia), Assoc. Prof. Baiba Mauriņa (Latvia)
10:30–11:00	Design and Development of Fluorinated Amphiphilic Lipids Based on 1,4-Dihydropyridine Core for Advanced Delivery Applications Aiva Plotniece, Latvia
10:30–11:00	Development of Marine Polysaccharide and Silk Fibroin Hydrogels Elīna Ķelle, Latvia
12:30–13:30	Patients’ Opinions on Pharmacy Staff Consultation Quality in the Community Pharmacy Renāte Teterovska, Latvia
12:30–13:30	Drug Release Individualisation from FDM 3D-Printed Oral Dosage Form of Prednisolone Valentyn Mohylyuk, Latvia
12:30–13:30	Taste-Masked Pellets of Sodium Warfarin, Prepared by Hot Melt Extrusion Valentyn Mohylyuk, Latvia
12:30–13:30	Enhancing Nanoparticle Features Through Ethylene-Bridged Cationic Moieties and Branched Ester Chains in the 1.4-Dihydropyridine Core Anete Upīte, Latvia
15:00–15:30	Formulation and Evaluation of Orally Disintegrating Tablets (ODTs) of Poorly Soluble API Celecoxib Using Amorphous Solid Dispersion (ASD) Techniques Oxana Brante, Latvia
15:00–15:30	Preliminary Screening of Antibacterial Activity of Berry Juice of Sorbus aucuparia Cultivars Growing in Latvia Rudīte Koka, Latvia

Keynote Speakers

Henri Leinonen

School of Pharmacy, University of Eastern Finland

Scientific Committee

• Asst. Prof. Agnese Brangule, Department of Pharmaceutical Chemistry, Rīga Stradiņš University
• Konstantīns Logviss, Head of Laboratory of Finished Dosage Forms, Rīga Stradiņš University
• Assoc. Prof. Baiba Mauriņa, Vice-Dean, Faculty of Pharmacy, Rīga Stradiņš University
• Valentyn Mohylyuk, Leading visiting researcher, Faculty of Pharmacy, Rīga Stradiņš University
• Asst. Prof. Inga Urtāne, Head of Department of Pharmaceutical Chemistry, Rīga Stradiņš University
• Prof. Valdas Jakštas, Lithuanian University of Health Sciences (LSMU)

Main Topics

• Pharmaceutical Science
• Drug delivery systems 

Dental and Maxillofacial Sciences

28 March. Auditorium #1, RSU, 16 Dzirciema iela

Dental and Maxillofacial Sciences will focus on medical research, integrating cutting-edge technology and interdisciplinary approaches to improve patient care and outcomes in the oral and maxillofacial regions, innovations and translating scientific discoveries.

28 March. Agenda

Session I: Oral and Maxillofacial Surgery Chair: Assoc. Prof. Linda Z. Arvidsson (Norway), Assoc. Prof. Laura Neimane (Latvia)
9:00–9:15	Two-Year Clinical Outcomes of Third Molar Autotransplantation: A Clinical Trial of 52 Patients Miks Lejnieks, Latvia
9:15–9:30	Maxilla Tumor Pre-Operative Virtual Planning in Patients Undergoing Reconstructive Surgery with Microvascular Bone Flaps Jānis Zariņš, Latvia
9:30–9:45	Three-Dimensional Printing and Planning in the Management of Acute Isolated Orbital Floor Fractures Ilze Prikule, Latvia
9:45–10:30	Lecture: Imaging of the TMJ –  A radiological Research Perspective from the University of Oslo Linda Z. Arvidsson, Norway
10:30–11:00	Break
Session II: Dentistry and Related Sciences Chair: Assoc. Prof. Ville Vuollo (Finland), Assoc. Prof. Andris Ābeltiņš (Latvia)
11:00–11:45	Lecture: Analysing Craniofacial 3D Surface Models in Dentistry Ville S. Vuollo, Finland
11:45–12:00	The Relationship Between Maxillary Transverse Dimension and Impacted Canines Ieva Ozola, Latvia
12:00–12:15	Infraocclusion of Retained 2nd Mandibular Primary Molars in Case of 2nd Mandibular Permanent Premolar Agenesis Dita Meistere, Latvia
12:15–12:30	Immunological and Anti-Microbial Activity of Platelet-Rich Fibrin Lana Mičko, Latvia
12:30–13:30	Break
Session III Chair: Prof. Ilze Akota (Latvia), Assoc. Prof. Anda Slaidiņa (Latvia)
13:30–13:45	Comparative Analysis of Prophage Gene Content in Veillonella Atypica Isolates from a Periodontitis Patient and Healthy Individuals: A Pilot Study Alisa Kazarina, Latvia
13:45–14:00	The Role of Biochemical and Microbiological Properties of Granulation Tissue in Periodontal Regeneration Dārta Elizabete Emuliņa, Latvia
14:00–14:15	A New Approach to the Non-Surgical Management of Periodontal Furcation Involvement Defects – A Study Protocol Anete Vaškeviča, Latvia
14:15–14:30	Challenges and Opportunities in Adopting Minimally Invasive Caries Management: Perspectives from Latvian Dental Hygienists Una Stāmere, Latvia
14:30–14:45	Economic Evaluation for Minimal Intervention Paediatric Caries Management Strategies in Latvia Olga Sļepcova, Latvia
14:45–15:00	Validation of Lower Digital Dental Models Superimposition Methods, Marija Gūtmane, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #1 Committee: Assoc. Prof. Anda Slaidiņa (Latvia), Assoc. Prof. Ilze Maldupa (Latvia)
10:30–11:00	Evaluation of Spheno-Occipital Synchondrosis as an Age Estimation Tool Using Cone-Beam Computed Tomography in Latvian Individuals Zanda Bokvalde, Latvia
10:30–11:00	Management of Occlusoproximal Caries Lesions in Primary Teeth: A Systematic Review and Network Meta-Analysis Jonathan Rafael Garbim, Brazil
Committee: Assoc. Prof. Sergio Uribe (Latvia), Asst. Prof. Ilze Šalma (Latvia)
12:30–13:30	Prevalence of Middle Mesial Root Canal and the Related Variations in the Canal Anatomy in Mandibular First Molars: A Cone-Beam Computed Tomographic Study Elīna Gribeļska, Latvia
12:30–13:30	Possible Role of Epstein-Barr Virus (EBV) and Human Herpesvirus 7 (HHV-7) Infection in Pathogenesis of Recurrent Aphthous Stomatitis Jagriti Kakar, Latvia
12:30–13:30	Satisfaction and Patient-Related Outcomes with the Care and Use of a Single Metal-Ceramic Crown After an 8-Year Wearing Period Elīna Blūma, Latvia
12:30–13:30	Presence of Temporary Cement in Dentine Tubules After Removal of Temporary Restoration. SEM Analysis. In Vitro Study Sanita Grīnberga, Latvia
12:30–13:30	Development and validation of the Latvian version of the Orofacial Esthetic Scale Māra Gaile, Latvia

Keynote Speakers

Assoc. Prof. Linda Arvidsson

University of Oslo, Norway

Assoc. Prof. Ville Vuollo

University of Oulu, Finland

Scientific Committee

• Prof. Ilze Akota, Rīga Stradiņš University
• Prof. Ingrīda Čēma, Rīga Stradiņš University
• Assoc. Prof. Laura Neimane, Rīga Stradiņš University
• Assoc. Prof. Andris Ābeltiņš, Rīga Stradiņš University
• Asst. Prof. Ilze Šalma, Rīga Stradiņš University
• Prof. Ulvi Gursoy, Turku University, Finland

Main Topics

• Dentistry and related sciences
• Oral and Maxillofacial Surgery
• Biomaterials

Medical Diagnostics Evolution: From Morphology and Radiology to New Frontiers

28 March. From Past to Modern Morphology. Agenda

Room 204, RSU, 21 Konsula iela

The beauty of Histology reveals the inside of tissue and organs, but the other subdiscipline of Morphology – Anthropology displays the magnificence of body changes in external shape during the centuries. These subjects never persist separately but overlap with developmental Biology and Histopathology resulting in whole Morphology science. Thus, this section will focus on polymorphous Morphology including even an artificial intelligence and 3D printing aspects of nowadays subject.

Agenda

Session I Chair: Prof. Māra Pilmane (Latvia)
9:00–9:30	Advancing Neurological Disease Diagnostics: From Tissue Staining and Sequencing to AI-Assisted Language and Vision Models Zane Jaunmuktane, UK
9:30–10:00	Evaluation of sociocultural factor effects on general health status in Late Medieval to Early Modern Vilnius Inhabitants Rimantas Jankauskas, Lithuania
10:00–10:30	Can Anatomy Still Offer a Terra Incognita for Scientists? David Kachlik, Czechia
10:30–11:00	Break
Session II Chair: Prof. Māra Pilmane (Latvia), Prof. Valērija Groma (Latvia)
11:00–11:30	Two Weeks Changes in Cytokines and Antimicrobial Proteins of Milk in Mastitis-Affected Free-Stall Barn Cows Māra Pilmane, Latvia
11:30–12:00	Appearance and Distribution of Voltage-Gated Sodium Channels in Excitable and Non-excitable Cells of the Human Brain Valērija Groma, Latvia
12:00–12:30	Anthropological Investigations of the Population of Latvia in the 21st Century Jānis Vētra, Latvia
12:30–13:30	Break
Session III Chair: Prof. Jānis Vētra (Latvia)
13:30–14:00	Multiform Morphology in the Digital Age: Evolution of Anatomical Studies with Virtual Dissection and 3D Printing Dzintra Kažoka, Latvia
14:00–14:20	Automatic Segmentation of Morphological Structures, Metastasis Detection, and 3D Model Reconstruction from Medical Imaging Utilizing Artificial Intelligence Based on Deep Neural Network Methodologies Edgars Edelmers, Latvia
14:20–14:40	Chronic Rhinosinusitis with Nasal Polyps in Latvia Rūdolfs Vīksne, Latvia
14:40–15:00	A Comparative Study of Acquired Cholesteatoma in Pediatric and Adult Populations Kristaps Dambergs, Latvia
15:00–15:30	Break
Session IV Chair: Prof. Ilze Štrumfa (Latvia), Assoc. Prof. Liāna Pļaviņa (Latvia)
15:30–15:50	Aberrant Epithelial-Mesenchymal Transition in Parathyroid Pathology Romans Uļjanovs, Latvia
15:50–16:20	Elaboration of Morphological Model to Evaluate Long-Term Hepatobiliary Consequences of Covid-19 Ilze Štrumfa, Latvia
16:20–16:40	Evaluation of 12 Cleft Candidate Gene Proteins in Human Cleft Lip and Palate Tissue Mārtiņš Vaivads, Latvia
16:40–17:00	Identification of Distinct Osteoarthritis Subgroups via Cluster Analysis Sofija Semeņistaja, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #6 Committee: Asst. Prof. Anna Junga (Latvia), Asst. Prof. Mārtiņš Vaivads (Latvia)
10:30–11:00	The Evaluation of Human Beta Defensin-2, 3, 4 and Apoptosis in Placentas of Different Gestational Ages Anna Junga, Latvia
10:30–11:00	Characterization of Galactin (Gal-10) in Cleft Lip Palate (CLP) Affected Tissue Alise Elizabete Rone, Latvia
12:30–12:40	CDX1, SHH, IHH Genes and Their Protein’s Role in Ladd’s Band Development Evelīna Pivrika, Latvia
12:40–12:50	Anthropometric Analysis of Children Aged 1 to 15 Years in Piebalga, Latvia Arta Grabicka, Latvia
Committee: Assoc. Prof. Dzintra Kažoka (Latvia), Assoc. Prof. Silvija Umbraško (Latvia)
12:50–13:00	Analysis of Cephalic Index in Latvian Residents from Different Regions Based on 1930s Data Lāsma Asare, Latvia
13:00–13:10	The Association Between Body Mass Index, Blood Pressure and Resting Heart Rate in Adults from Piebalga, Latvia Līva Kuzmane, Latvia
13:10–13:20	Anthropometric Data Insights from Detailed Measurements in Piebalga, Latvia Arta Grabicka, Latvia

28 March. Radiological Patterns and Cognitive Function and  Radiology – From Pictures to Interventions and Beyond. Agenda

Room 305, RSU, 21 Konsula iela 

The section meeting will update information and research results on the development of an integrated approach to assessing cognitive abilities in patients with neurodegenerative diseases of the central nervous system, research and opportunities in interventional radiology, the development and application of artificial intelligence in neuroradiology, and current events and innovations in radiology.

Session I: Neuroradiology-Cognitive Patterns Chair: Prof. Ardis Platkājis (Latvia), Prof. Jurģis Šķilters (Latvia)
9:00–9:30	Parkinson's Disease MRI Biomarkers: Quantifying Neuromelanin with High-Resolution Imaging Artūrs Šilovs, Latvia
9:30–10:00	Neurodegenerative Impacts on Different Levels of Cognitive Processing: Evidence from Mid-Level Vision and Spatial Cognition Jurģis Šķilters, Latvia
10:00–11:00	Break
Session II Chair: Nauris Zdanovskis (Latvia)
11:00–11:30	From Ultrasound-Guided to CT-Guided Procedures Nauris Zdanovskis, Latvia
11:30–12:00	Interventions in Liver: Transarterial Chemoembolization (TACE) and Microwave Ablation (MWA) Aina Kratovska, Latvia
12:00–12:30	Interventions in Kidney: Biopsies and Tumour Focal Ablations Artūrs Šilovs, Latvia
12:30–13:30	Break
Session III Chair: Assoc. Prof. Maija Radziņa (Latvia), Asst. Prof. Arturs Balodis (Latvia)
13:30–13:50	Predictors of Poor Long-Term Outcomes After Successful Thrombectomy in Large Vessel Acute Ischemic Stroke Maija Radziņa, Latvia
13:50–14:10	Enhancing Ischemic Stroke Diagnosis: The Role of MRI in Acute Management Arturs Balodis, Latvia
14:10–14:30	Integrative Analysis of Carotid Plaque Instability: Multimodal Ultrasound, CTA, and Histology in Focus Andrejs Ļioznovs, Latvia
14:30–14:50	Developing and Testing an AI-based Tool for Acute Ischemic Stroke Detection in Non-enhanced CT (NECT) Andris Veiss, Latvia

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #7 Committee: Prof. Ardis Platkājis (Latvia), Asst. Prof. Arturs Balodis (Latvia)
10:30–10:40	Simulation-Based Assessment of Proton Radiography Across Energy Levels: Investigations on Optimum Imaging Energy Aurēlija Viņķe, Latvia
10:40–10:50	Challenges in Differentiating Stroke Mimics from Acute Ischemic Stroke: Case Analysis and Imaging-Based Diagnostic Approaches Kalvis Vērzemnieks, Arturs Balodis, Latvia
Committee: Assoc. Prof. Maija Radziņa (Latvia), Asst. Prof. Arturs Balodis (Latvia)
12:30–12:40	Ultrasound in the Diagnosis of Upper Limb Lymphedema Miroslav Černický, Slovakia
12:40–12:50	Differential Diagnostic Challenges in the Evaluation of Optic Nerve Glioblastoma with Extensive Spread to the Anterior Cranial Fossa Artis Brokāns, Latvia
12:50–13:00	Bowel Traumatic Injury in Polytrauma Patients CT Scan Comparison with Acute Surgical Findings and Most Likely Complications Aleksejs Rivars, Latvia
Committee: Prof. Ardis Platkājis (Latvia), Prof. Kārlis Kupčs (Latvia)
13:00–13:10	Pre-Treatment Predictive Radiological Parameters of Rectal Cancer Response to Neoadjuvant Chemoradiation Therapy Linda Kokaine, Latvia
13:10–13:20	Multiparametric Ultrasound Evaluation of Long-Term Liver Damage in COVID-19 Maija Radziņa, Latvia
13:20–13:30	Mesenterial Blood Vessel Traumatic Injury in Polytrauma Patients CT scan Comparison with Acute Surgical Findings and Most Likely Complications Emīls Talačka, Latvia

Keynote Speakers

From Past to Modern Morphology

David Kachlík

Charles University, Czech Republic

Zane Jaunmuktane

National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, London, UK

Rimantas Jankauskas

Vilnius University, Lithuania

Radiological Patterns and Cognitive Function and  Radiology - from pictures to interventions and beyond

Prof. Baingio Pinna

Department of Biomedical Sciences, University of Sassari, Italy

Scientific Committee

From Past to Modern Morphology

• Prof. Māra Pilmane, Rīga Stradiņš University
• Andrejs Ivanovs, MD MSc PhD MRCP(UK) FRCPath, Department of Haematology, Edinburgh Cancer Centre, UK
• Asst. Prof. Anna Junga, Rīga Stradiņš University
• Assoc. Prof. Dzintra Kažoka, Rīga Stradiņš University

Radiological Patterns and Cognitive Function and  Radiology - from pictures to interventions and beyond

• Prof. Ardis Platkājis, Head of Department of Radiology, Rīga Stradiņš University
• Assoc. Prof. Maija Radziņa, Department of Radiology, Rīga Stradiņš University
• Asst. Prof. Nauris Zdanovskis, Department of Radiology, Rīga Stradiņš University
• Prof. Jurgis Sķilters, Chair of Laboratory for Perceptual and Cognitive Systems at the Faculty of Computing, University of Latvia

Main Topics

From past to modern Morphology

• Anthropology  
• Histology  
• Embryology and teratology  
• Histopathology 

Radiological Patterns and Cognitive Function 

• Imaging (Radiology) 
• Neuroimaging

Psychiatry

28 March, Auditorium #2, RSU, 16 Dzirciema iela

Agenda

Session I: Women's Mental Health in Post-Partum Period Chair: Prof. Elmārs Rancāns (Latvia), Asst. Prof. Ļubova Renemane (Latvia)
9:00–9:15	Assessment of Mental Health Service Utilization During the Peripartum Period in Rīga Maternity Hospital and National Mental Health Centre: A 12-Month Overview Linda Rubene
9:15–9:30	Six-Month Findings on the Prevalence and Severity of Depressive Symptoms and Their Associations with Sociodemographic Characteristics in Postpartum Women Attending Outpatient Clinic Marija Lazareva
9:30–9:45	Eosinophilic Oesophagitis as an Underlying Cause of Patients Admitted with Food Bolus Obstruction under Otorhinolaryngologists in East of Scotland Marija Lazareva
9:45–10:00	Postpartum Anxiety and Sociodemographic Factors: Preliminary Results from a 6-Month Cross-Sectional Study in Latvia Silvija Cīpare
10:00–10:15	New Postpartum Mental Health Care Model in Latvia: A Qualitative Evaluation by the Postpartum Women Elīna Zelčāne
10:15–10:30	The Association Between Psychosocial Factors and Generalized Anxiety Symptoms in Women During the First Postpartum Year Paula Kovaļevska
10:30–11:00	Break
Session II: Child and Youth Mental Health: Focus on Screening and Interventions Chair: Asst. Prof. Ņikita Bezborodovs (Latvia), Lect. Zane Gulbe (Latvia)
11:00–11:15	The Correlation Between Generalized Anxiety Symptoms and Adverse Childhood Experiences Among Pregnant Women in Latvia Lelde Logina
11:15–11:30	Recent Advances in the Development of Screening Instruments for Early Recognition of Mental, Behavioural and Neurodevelopmental Disorders in Latvian Children and Adolescents Ņikita Bezborodovs
11:30–11:45	Bullying as a Risk Factor for Suicidal Behavior in Latvian Adolescents: A Population-Based Study Marija Terēze Melzupe
11:45–12:00	Emotional and Behavioural Difficulties and Perception of Threat in Latvian Adolescents: A population-based study Kristīne Kozlova
12:00–12:15	Internet-based Cognitive Behavioural Therapy for Adolescents and Young Adults with Depression and Anxiety: A Study Protocol for an Implementation Study Liene Dambiņa
12:15–12:30	Arts-Based Interventions Incorporating Myths for Adolescents: A Scoping Review Anita Bernāne
12:30–13:30	Break

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

10:40–11:00	Factors Influencing Depression Incidence in Latvian Family Medicine Doctors During Covid-19 Pandemic from January to March 2022 Lilija Ķēniņa
10:40–11:00	Practical Application of Sherborne Developmental Movement in Professional Practice: Insights from Practitioners in Latvia, the Netherlands, and the UK Diāna Semerova
12:30–13:00	The Correlation Between Anxiety and Depression Symptoms and Perceived Stress and Burnout in the Population of Latvian Radiographers and Radiology Assistants Laura Saulīte
12:30–13:00	Correlation Between Depression, Anxiety and Somatic Symptoms Among Radiographers and Radiology Assistants in Latvia Marta Zande
12:30–13:00	Correlation Between Depression, Anxiety Symptoms, Self-Esteem, and Different Coping Strategies Among Radiology Assistants and Radiographers in Latvia Marta Zande
10:40–11:00	Changes in Scores of Alexithymia Before and After Treatment in Inpatient Psychotherapeutic Programme (Minnesota) in Patients with Substance Use Disorder Līva Mača
10:40–11:00	Clozapine Use in the Pediatric Population: Clinical Case Report and New Guidelines at Children’s Clinical University Hospital, Latvia Laura Ķevere
12:30–13:00	Correlation Between Depression, Anxiety Symptoms, and Self-Esteem Among Radiology Assistants and Radiographers in Latvia Lelde Smilte-Breča
12:30–13:00	The Correlation Between Depression, Anxiety Symptoms, and Work-Life Conflict Among Radiology Assistants and Radiographers Ilze Madara Brūvere
12:30–13:00	The Association Between Self-esteem, Relationship Satisfaction, and Work-Life Conflict Among Radiology Assistants and Radiographers Ilze Madara Brūvere

Multidsiciplinary Sessions

26 March. Traumatology & Orthopaedics. Agenda

Room #305, RSU, 21 Konsula iela

Session I Chair: Prof. Andris Jumtiņš (Latvia), Dr. med. Uldis Krustiņš (Latvia)
9:00–9:07	Challenges and Strategies in Managing Femoral Neck Fractures in Patients Over 40 Years of Age Andris Džeriņš, Latvia
9:10–9:17	The Prevalence of Asymptomatic Rotator Cuff Tears in Individuals Aged 40–70 years Andrejs Peredistijs, Latvia
9:20–9:27	Comparison of the Results of Arthroscopic Treatment Methods for Anterior Shoulder Instability Andrejs Finogejevs, Latvia
9:30–9:37	Arthroscopic Treatment of Chronic Synovitis in Patients with Post-Traumatic Knee Osteoarthritis Murodulla Karimov, Uzbekistan
9:40–9:47	Diagnosis and Treatment Gap of Osteoporosis in Patients with Proximal Femur Fragility Fracture Valts Boginskis, Latvia
9:50–9:57	The Comparisons of Physical Functional Performances Between Older Adults with and without Sacroplasty Surgery for Traumatic Lateral Mass Fractures of the Sacrum Agris Mertens, Latvia
10:00–10:07	The Reconstruction of Metacarpal Bones with Free Deep Circumflex Iliac Artery (DCIA) Microvascular Bone Flap Sergejs Kižlo, Latvia
10:10–10:17	Development and Validation of a Prognostic Risk Scale for Predicting Compartment Syndrome in Tibial Fracture Patients Otabek Abdulazizov, Uzbekistan
10:20–10:27	Nanofractured Autologous Matrix-Induced Chondrogenesis (N-AMIC) Technique for Focal Knee Cartilage Defects: Clinical Case Report Eduards Toms Morītis, Latvia
10:30–11:00	Break
Session II Chair: Assoc. Prof. Pēteris Studers (Latvia), Dr. Andris Džeriņš (Latvia)
11:00–11:07	Salvage Procedures in Most Common Carpal Problems. Experience and results of the Microsurgery Centre of Latvia Uldis Krustiņš, Latvia
11:10–11:17	Cefazolin Concentration in Synovial Fluid During Elective Knee Joint Arthroplasty: Evaluation of Standardized Antibiotic Prophylaxis and Influencing Factors Una Baldiko, Latvia
11:20–11:27	Custom Cutting Guides in Oncological Orthopedic Surgery: Our Experience Davide Matera, Italy
11:30–11:37	Surgical Treatment Methods and Outcomes of Periprosthetic Shoulder Infection Sergejs Kižlo, Latvia
11:40–11:47	MODIC Type Endplate Changes as a Modifier for Cephazolin Penetration into the Intervertebral Disc Aleksejs Repņikovs, Latvia
11:50–11:57	Evaluating Acetabular Orientation and Leg Length Discrepancy Correction in Total Hip Arthroplasty for Severe Hip Dysplasia Sarvar Madrakhimov, Uzbekistan
12:00–12:07	Long Term Results of Total Hip Arthroplasty in DDH Patients with Secondary Osteoarthritis Silvestris Zēbolds, Latvia
12:10–12:17	Comparative Efficacy of Twice-Yearly Versus Annual Zoledronic Acid Administration in Post-COVID Avascular Necrosis of the Hip Sarvar Madrakhimov, Uzbekistan
12:20–12:27	Surgical Treatment of Severe Hallux Valgus: Mid-Term Outcome Evita Rumba, Latvia
12:30–13:30	Break

Poster presentations

Venue: Cafeteria, RSU, 16 Dzirciema iela

10:30–11:00	The Impact of Preoperative Preparation on Treatment Outcomes of Proximal Femoral Fractures in Elderly Patients Nodir Kobilov, Uzbekistan
10:30–11:00	Optimization of Surgical Treatment for Patients with Long Bone Fractures of the Lower Limb in Cases of Multiple Injuries Fakhriddin Salokhiddinov, Uzbekistan
12:30–13:30	The Finite Element Method Applied in the Biomechanical Assessment of the Acromio-Clavicular Joint Bogdan Marandiuc, Moldova
12:30–13:00	Peculiarities of the Biomechanical Properties of the Femoral Head at Osteoarthritis and Avascular Necrosis Pēteris Studers, Latvia
12:30–13:00	Mental Health and Cognitive Function Among Patients with Symptomatic Hand or Large Joint Osteoarthritis Undīne Zeltiņa, Latvia

26 March. Ophthalmology. Agenda

Room #305, RSU, 21 Konsula iela

Session I Chair: Prof. Guna Laganovska (Latvia), Asst. Prof. Juris Vanags (Latvia)
13:30–13:37	Evaluating the 3-Hydroxykynurenine / Kynurenic Acid Ratio as a Diagnostic Biomarker for Cataract Progression Artūrs Zemītis, Latvia
13:40–13:47	Evaluating the Effect of Intravitreal Anti-VEGF Treatment on Radiation-Induced Maculopathy in Choroidal Melanoma Patients Eva Mediņa, Latvia
13:50–13:57	Effect of Anti-VEGF Drug Therapy on Foveal Thickness in AMD Patients with Serous RPE Detachment Mārtiņš Brūveris, Latvia
14:00–14:07	Effective Timing and Surgical Approach: Optimizing Outcomes in Bilateral Macular Holes – A Case Report Anija Evelīna Gulbe, Latvia
14:10–14:17	Redetachment Rates and Clinical Outcomes Following Pars Plana Vitrectomy for Retinal Detachment at Pauls Stradiņš Clinical University Hospital (2023–2024) Diāna Lavrinoviča, Latvia
14:20–14:27	Cataract Lens Morphology Analysis in Patients with Exposure to Extremely Increased Doses of Radiation (Chornobyl Ex Clean-up Workers) and Its Comparison with Non-Exposed Individuals Elza Grīsle, Latvia
14:30–14:37	Incidence of Pattern Dystrophy and Its Impact to Visual Acuity within Latvijas–Amerikas acu centrs Patients Agnese Vikmane, Latvia
14:40–14:47	Multidisciplinary Approach for Treatment of Complicated Graves’ Disease Orbitopathy: Case Report Dita Elīna Sila, Latvia
14:50–14:57	Exploring the Role of Bioinformatics in Identifying Genetic Markers for Diabetic Retinopathy: Current Approaches and Prospects for Advancement Ecaterina Pavlovschi, Moldova

26 March. Anaestesiology and Intensive Care Poster Presentations. Agenda

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #2 Committee: Māra Klibus (Latvia), Asst. Darja Smirnova (Latvia)
10:30–10:40	Case Report: Necrotizing Fasciitis in a 38-Year-Old Female with History of Intravenous Drug Use Dmitrijs Semjonovs, Latvia
10:40–10:50	Clinical Efficacy of the Oxiris® Membrane in Patients with Refractory Septic Shock: Comparison Between Isolated Hemadsorption and Continuous Veno-Venous Hemofiltration Modalities Dāvis Niks Pretkalniņš, Latvia
10:50–11:00	Transversus Abdominis Plane (TAP) Block for Postoperative Analgesia in Patients after Iliac Artery Repair Anastasija Rabša, Latvia
12:30–12:40	Impact of Transversus Abdominis Plane Block on Postoperative Analgesia in Ileostomy Closure Surgery: A Prospective Cohort Study Oksana Sedova, Latvia
12:40–12:50	Effect of Type of Anaesthesia on Pain, Mental Status and Patient Satisfaction after Elective Total Hip Replacement Surgeries Linda Strēlniece, Latvia
12:50–13:00	Anterior Quadratus Lumborum Block for Postoperative Pain Management in Colorectal Surgery: A Case Series Oļegs Gutņikovs, Latvia
13:00–13:10	Choice of Tactics in Airway Management for Otorhinolaryngology-Oncological Patients: A Three-Case Series Analysis Arvīds Bērziņš, Latvia
13:10–13:20	Possible Complications and Techniques of Anesthesia During Thyroid Tumour Resection with Tracheal Deviation and Main Vessels Compression: A Clinical Case Ekaterina Zhuravleva, Latvia
13:20–13:30	Patients' Satisfaction with General Anesthesia or Spinal Anesthesia During Hip Replacement Surgery Renāte Demičeva, Moldova

26 March. Assorted Poster Presentations. Agenda

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #6 Committee: Linda Gailīte (Latvia)
12:30–12:40	Mice Breeding Strategies: Pair Vs Trio Madara Kreišmane, Latvia
12:40–12:50	Initial Insights from Shallow Whole Genome Sequencing (sWGS) of Seminal Plasma Cell-Free DNA in Idiopathic Male Infertility Marija Lazovska, Latvia
12:50–13:00	Characterisation of GSTM1 and GSTT1 Genetic Variability and Its Role in the Development of Drug-Induced Hepatotoxicity in Patients with Drug-Susceptible Pulmonary Tuberculosis Ilga Kivleniece, Latvia
Committee: Prof. Ilona Hartmane (Latvia)
13:00–13:10	Effect of Kinesiotaping in Treatment of Cellulite: Metodological Approach of Effect on Skin Texture and Structure Jurgita Boltutienė, Lithuania
13:10–13:20	Dermatoscopy in the Diagnostics of Benign Formations and Malignant Cancers of the Skin Andra Dērveniece, Latvia

27 March. Neurology Poster Presentations. Agenda

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #6 Committee: Prof. Andrejs Millers (Latvia), Assoc. Prof. Zanda Priede (Latvia)
10:30–10:40	Plasma Neurofilament Light Chain as a Biomarker of Disease Progression and Brain Atrophy in Relapsing-Remitting Multiple Sclerosis Kristiāna Beča, Latvia
10:40–10:50	Correlation of Neurodegenerative Biomarkers and Functional Outcome in Patients with Multiple Sclerosis Monta Feldmane, Latvia
10:50–11:00	Anxiety, Depression and Somatisation Disorder in Low Back Pain Patients. What to Expect from These Patients Kārlis Stirāns, Latvia
Committee: Prof. Guntis Karelis (Latvia), Asst. Prof. Daina Pastare (Latvia)
12:30–12:40	Chronic Low Back Pain: Recognising and Mitigating Management Challenges Toms Ceriņš, Latvia
12:40–12:50	Migraine-Type Headache in Children at Children’s Clinical University Hospital Arita Elizabete Rakste, Latvia
12:50–13:00	Trigeminal Neuralgia in Multiple Sclerosis Patients: Short Case Series Jolanta Ošiņa, Latvia
13:00–13:10	Evaluating Changes in Initial Diagnosis and Treatment of Multiple Sclerosis with Updated Diagnostic Criteria: Retrospective Study Sabīne Teifurova, Latvia
13:10–13:20	Vitamin D and Newly Diagnosed Multiple Sclerosis Katerīna Osinoveca, Latvia

28 March. Assorted Poster Presentations. Agenda

Venue: Cafeteria, RSU, 16 Dzirciema iela

Screen #2

13:10–13:20	Ancient DNA Analysis of Archaeological Tooth Sample as an Opportunity to Examine Ancient Microbial Genomic Content Committee: Linda Gailīte (Latvia), Anda Slaidiņa (Latvia) Alise Pokšāne, Latvia
13:20–13:30	Boosting Simulation Programs Through Student Initiatives: Enhancing Medical Education Through Active Student Engagement Committee: Ingus Skadiņš (Latvia) Aleksandrs Oborins, Latvia

Screen #3

Committee: Assoc. Prof. Ingus Skadiņš (Latvia)
13:10–13:20	Analysis of Foreign Scientific Relations and Business Trips of the Academic and Scientific Staff of the Rīga Medical Institute in the Period from 1950 to 1991 Kaspars Antonovičs, Latvia
Committee: Asst. Prof. Ņikita Bezborodovs (Latvia)
13:30–13:30	From the Doctor's Office to the Public Stage: Hypnosis in Soviet Latvia Ieva Lībiete, Latvia

Screen #5

Committee: Assoc. Prof. Andris Skride (Latvia), Valdis Ģībietis (Latvia)
12:30–12:40	Musculoskeletal Involvement in Patients with Hereditary Hemochromatosis Ilva Bikanova, Latvia
12:40–12:50	Pneumomediastinum as COVID-19 Complication in Hospitalized Patients – A Retrospective Study Inese Muceniece, Latvia
Committee: dr. Aleksandrs Maļcevs (Latvia)
12:50–13:00	Emergency Cholecystectomy Vs Bridging Cholecystostomy for Moderate and Severe Acute Cholecystitis: A Retrospective Cohort Study Margarita Ptašņuka, Latvia
13:00–13:10	Management of Rare Complication After Nuss Procedure Ričards Gurins, Latvia